FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978215316> ?p ?o ?g. }

• W1978215316 endingPage "311" @default.
• W1978215316 startingPage "302" @default.
• W1978215316 abstract "Although great progress has been made in the characterization of the biochemical and biological features of hepatitis C virus (HCV) gene expression, the elucidation of the HCV life cycle and the evaluation of novel antiviral strategies have been hindered by the lack of a suitable cell culture system. In this context, the development of an efficient HCV cDNA delivery method would contribute to the understanding of HCV replication. To assess the functionality of baculovirus mediated gene delivery for HCV expression, we have constructed recombinant baculoviruses encoding HCV cDNA under the control of the cytomegalovirus promoter. Transduction of the human hepatoma cell line Huh-7 with Bac–HCV vectors was efficient and HCV cDNA expression was enhanced by treatment of the infected cells with dexamethasone. HCV structural and nonstructural polypeptides were processed correctly and were found to localize in the cytoplasm in a pattern characteristic of the endoplasmic reticulum. The expression of the HCV proteins was detected for 49 days after infection. Thus, these results indicate that the recombinant Bac–HCV vectors are a useful tool for the delivery of HCV cDNA and can facilitate the analysis of structural and functional properties of the HCV proteins. In addition, the Bac–HCV vectors can provide important information on the evaluation of novel anti-HCV antiviral strategies." @default.
• W1978215316 created "2016-06-24" @default.
• W1978215316 creator A5048798727 @default.
• W1978215316 creator A5062802371 @default.
• W1978215316 creator A5084807920 @default.
• W1978215316 date "1999-03-01" @default.
• W1978215316 modified "2023-10-17" @default.
• W1978215316 title "Expression of Hepatitis C Virus cDNA in Human Hepatoma Cell Line Mediated by a Hybrid Baculovirus–HCV Vector" @default.
• W1978215316 cites W1581048386 @default.
• W1978215316 cites W1595782547 @default.
• W1978215316 cites W1605520753 @default.
• W1978215316 cites W1673662691 @default.
• W1978215316 cites W1773837359 @default.
• W1978215316 cites W1836032532 @default.
• W1978215316 cites W1847011379 @default.
• W1978215316 cites W1877659824 @default.
• W1978215316 cites W1913577888 @default.
• W1978215316 cites W1914838920 @default.
• W1978215316 cites W1914884504 @default.
• W1978215316 cites W1928472258 @default.
• W1978215316 cites W1957867949 @default.
• W1978215316 cites W1964315952 @default.
• W1978215316 cites W1971792395 @default.
• W1978215316 cites W1976844675 @default.
• W1978215316 cites W1979919755 @default.
• W1978215316 cites W1990237653 @default.
• W1978215316 cites W1998091480 @default.
• W1978215316 cites W2005411001 @default.
• W1978215316 cites W2006309458 @default.
• W1978215316 cites W2008830376 @default.
• W1978215316 cites W2014303424 @default.
• W1978215316 cites W2018802169 @default.
• W1978215316 cites W2022741181 @default.
• W1978215316 cites W2029839079 @default.
• W1978215316 cites W2032451726 @default.
• W1978215316 cites W2045562270 @default.
• W1978215316 cites W2051767229 @default.
• W1978215316 cites W2052014046 @default.
• W1978215316 cites W2066124462 @default.
• W1978215316 cites W2066931983 @default.
• W1978215316 cites W2074188269 @default.
• W1978215316 cites W2076003033 @default.
• W1978215316 cites W2076780311 @default.
• W1978215316 cites W2089167315 @default.
• W1978215316 cites W2096466927 @default.
• W1978215316 cites W2097019995 @default.
• W1978215316 cites W2103202783 @default.
• W1978215316 cites W2115644966 @default.
• W1978215316 cites W2124528668 @default.
• W1978215316 cites W2125020009 @default.
• W1978215316 cites W2128055182 @default.
• W1978215316 cites W2151603470 @default.
• W1978215316 cites W2152071647 @default.
• W1978215316 cites W2152793674 @default.
• W1978215316 cites W2156634692 @default.
• W1978215316 cites W2160425277 @default.
• W1978215316 cites W2161945006 @default.
• W1978215316 doi "https://doi.org/10.1006/viro.1998.9565" @default.
• W1978215316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10069956" @default.
• W1978215316 hasPublicationYear "1999" @default.
• W1978215316 type Work @default.
• W1978215316 sameAs 1978215316 @default.
• W1978215316 citedByCount "43" @default.
• W1978215316 countsByYear W19782153162012 @default.
• W1978215316 countsByYear W19782153162014 @default.
• W1978215316 crossrefType "journal-article" @default.
• W1978215316 hasAuthorship W1978215316A5048798727 @default.
• W1978215316 hasAuthorship W1978215316A5062802371 @default.
• W1978215316 hasAuthorship W1978215316A5084807920 @default.
• W1978215316 hasBestOaLocation W19782153161 @default.
• W1978215316 hasConcept C104317684 @default.
• W1978215316 hasConcept C132379496 @default.
• W1978215316 hasConcept C151730666 @default.
• W1978215316 hasConcept C159047783 @default.
• W1978215316 hasConcept C187882448 @default.
• W1978215316 hasConcept C2522874641 @default.
• W1978215316 hasConcept C2776408679 @default.
• W1978215316 hasConcept C2779343474 @default.
• W1978215316 hasConcept C40767141 @default.
• W1978215316 hasConcept C54355233 @default.
• W1978215316 hasConcept C81885089 @default.
• W1978215316 hasConcept C83100098 @default.
• W1978215316 hasConcept C86803240 @default.
• W1978215316 hasConcept C92087593 @default.
• W1978215316 hasConceptScore W1978215316C104317684 @default.
• W1978215316 hasConceptScore W1978215316C132379496 @default.
• W1978215316 hasConceptScore W1978215316C151730666 @default.
• W1978215316 hasConceptScore W1978215316C159047783 @default.
• W1978215316 hasConceptScore W1978215316C187882448 @default.
• W1978215316 hasConceptScore W1978215316C2522874641 @default.
• W1978215316 hasConceptScore W1978215316C2776408679 @default.
• W1978215316 hasConceptScore W1978215316C2779343474 @default.
• W1978215316 hasConceptScore W1978215316C40767141 @default.
• W1978215316 hasConceptScore W1978215316C54355233 @default.
• W1978215316 hasConceptScore W1978215316C81885089 @default.
• W1978215316 hasConceptScore W1978215316C83100098 @default.
• W1978215316 hasConceptScore W1978215316C86803240 @default.
• W1978215316 hasConceptScore W1978215316C92087593 @default.

• next