FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978217966> ?p ?o ?g. }

• W1978217966 endingPage "1023" @default.
• W1978217966 startingPage "1018" @default.
• W1978217966 abstract "The mutation G48V in HIV-1 protease is a major resistance mutation against the drug saquinavir. Recently, G48V mutation is found to co-exist with the mutation C95F in AIDS patients treated with saquinavir. We report here the three-dimensional crystal structure of G48V/C95F tethered HIV-1 protease/saquinavir complex. The structure indicates following as the possible causes of drug resistance: (1) loss of direct van der Waals interactions between saquinavir and enzyme residues PHE-53 and PRO-1081, (2) loss of water-mediated hydrogen bonds between the carbonyl oxygen atoms in saquinavir and amide nitrogen atoms of flap residues 50 and 1050, (3) changes in inter-monomer interactions, which could affect the energetics of domain movements associated with inhibitor-binding, and (4) significant reduction in the stability of the mutant dimer. The present structure also provides a rationale for the clinical observation that the resistance mutations C95F/G48V/V82A occur as a cluster in AIDS patients." @default.
• W1978217966 created "2016-06-24" @default.
• W1978217966 creator A5019487756 @default.
• W1978217966 creator A5035946604 @default.
• W1978217966 creator A5056553016 @default.
• W1978217966 creator A5078894507 @default.
• W1978217966 creator A5084631279 @default.
• W1978217966 date "2010-06-01" @default.
• W1978217966 modified "2023-09-26" @default.
• W1978217966 title "Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex" @default.
• W1978217966 cites W1966952510 @default.
• W1978217966 cites W1968873679 @default.
• W1978217966 cites W1972227391 @default.
• W1978217966 cites W1974224443 @default.
• W1978217966 cites W1977282539 @default.
• W1978217966 cites W1980410659 @default.
• W1978217966 cites W1986191025 @default.
• W1978217966 cites W1988562891 @default.
• W1978217966 cites W1991781846 @default.
• W1978217966 cites W1993686151 @default.
• W1978217966 cites W1996607909 @default.
• W1978217966 cites W2013083986 @default.
• W1978217966 cites W2017436619 @default.
• W1978217966 cites W2019526592 @default.
• W1978217966 cites W2050957868 @default.
• W1978217966 cites W2056810821 @default.
• W1978217966 cites W2066109178 @default.
• W1978217966 cites W2071093060 @default.
• W1978217966 cites W2082650600 @default.
• W1978217966 cites W2084685050 @default.
• W1978217966 cites W2129155808 @default.
• W1978217966 cites W2169192079 @default.
• W1978217966 cites W2180229411 @default.
• W1978217966 cites W4210675630 @default.
• W1978217966 cites W4242482565 @default.
• W1978217966 doi "https://doi.org/10.1016/j.bbrc.2010.05.049" @default.
• W1978217966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20471372" @default.
• W1978217966 hasPublicationYear "2010" @default.
• W1978217966 type Work @default.
• W1978217966 sameAs 1978217966 @default.
• W1978217966 citedByCount "8" @default.
• W1978217966 countsByYear W19782179662013 @default.
• W1978217966 countsByYear W19782179662015 @default.
• W1978217966 countsByYear W19782179662017 @default.
• W1978217966 countsByYear W19782179662018 @default.
• W1978217966 countsByYear W19782179662019 @default.
• W1978217966 countsByYear W19782179662021 @default.
• W1978217966 crossrefType "journal-article" @default.
• W1978217966 hasAuthorship W1978217966A5019487756 @default.
• W1978217966 hasAuthorship W1978217966A5035946604 @default.
• W1978217966 hasAuthorship W1978217966A5056553016 @default.
• W1978217966 hasAuthorship W1978217966A5078894507 @default.
• W1978217966 hasAuthorship W1978217966A5084631279 @default.
• W1978217966 hasConcept C104317684 @default.
• W1978217966 hasConcept C112887158 @default.
• W1978217966 hasConcept C114851261 @default.
• W1978217966 hasConcept C142462285 @default.
• W1978217966 hasConcept C156719811 @default.
• W1978217966 hasConcept C159047783 @default.
• W1978217966 hasConcept C178790620 @default.
• W1978217966 hasConcept C181199279 @default.
• W1978217966 hasConcept C182707283 @default.
• W1978217966 hasConcept C185592680 @default.
• W1978217966 hasConcept C2776714187 @default.
• W1978217966 hasConcept C2776937687 @default.
• W1978217966 hasConcept C2777583353 @default.
• W1978217966 hasConcept C2779546866 @default.
• W1978217966 hasConcept C2993143319 @default.
• W1978217966 hasConcept C3013748606 @default.
• W1978217966 hasConcept C32909587 @default.
• W1978217966 hasConcept C501734568 @default.
• W1978217966 hasConcept C54355233 @default.
• W1978217966 hasConcept C55493867 @default.
• W1978217966 hasConcept C67705224 @default.
• W1978217966 hasConcept C71240020 @default.
• W1978217966 hasConcept C86803240 @default.
• W1978217966 hasConceptScore W1978217966C104317684 @default.
• W1978217966 hasConceptScore W1978217966C112887158 @default.
• W1978217966 hasConceptScore W1978217966C114851261 @default.
• W1978217966 hasConceptScore W1978217966C142462285 @default.
• W1978217966 hasConceptScore W1978217966C156719811 @default.
• W1978217966 hasConceptScore W1978217966C159047783 @default.
• W1978217966 hasConceptScore W1978217966C178790620 @default.
• W1978217966 hasConceptScore W1978217966C181199279 @default.
• W1978217966 hasConceptScore W1978217966C182707283 @default.
• W1978217966 hasConceptScore W1978217966C185592680 @default.
• W1978217966 hasConceptScore W1978217966C2776714187 @default.
• W1978217966 hasConceptScore W1978217966C2776937687 @default.
• W1978217966 hasConceptScore W1978217966C2777583353 @default.
• W1978217966 hasConceptScore W1978217966C2779546866 @default.
• W1978217966 hasConceptScore W1978217966C2993143319 @default.
• W1978217966 hasConceptScore W1978217966C3013748606 @default.
• W1978217966 hasConceptScore W1978217966C32909587 @default.
• W1978217966 hasConceptScore W1978217966C501734568 @default.
• W1978217966 hasConceptScore W1978217966C54355233 @default.
• W1978217966 hasConceptScore W1978217966C55493867 @default.
• W1978217966 hasConceptScore W1978217966C67705224 @default.
• W1978217966 hasConceptScore W1978217966C71240020 @default.

• next