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• W1978220518 abstract "This essay describes the evolution of stress as a medical scientific idea. Claude Bernard, Walter B. Cannon and Hans Selye provided key founding concepts for the current view. Bernard introduced the idea of the internal environment bathing cells—the milieu intérieur—maintained by continual compensatory changes of bodily functions. Cannon coined the word, “homeostasis,” referring to a set of acceptable ranges of values for internal variables. Cannon taught that threats to homeostasis evoke activation of the sympathoadrenal system as a functional unit. Selye defined stress as a state characterized by a uniform response pattern, regardless of the particular stressor, that could lead to long-term pathologic changes. “Allostasis” was introduced as a concept in recognition that there is no single ideal set of steady-state conditions in life; instead, setpoints and other response criteria change continuously. Stress is now viewed neither as a perturbation nor a stereotyped response pattern but as a condition characterized by a perceived discrepancy between information about a monitored variable and criteria for eliciting patterned effector responses. Different stressors elicit different patterns of activation of the sympathetic nervous, adrenomedullary hormonal, hypothalamic-pituitary-adrenocortical and other effectors, closing negative feedback loops. This systems concept of stress yields predictions that observation or experimentation can test and that are applicable to normal physiology and to a variety of acute and chronic disorders." @default.
• W1978220518 created "2016-06-24" @default.
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• W1978220518 date "2007-01-01" @default.
• W1978220518 modified "2023-10-06" @default.
• W1978220518 title "Evolution of concepts of stress" @default.
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• W1978220518 doi "https://doi.org/10.1080/10253890701288935" @default.
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