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- W1978220613 abstract "The antitumor drug VP-16 stabilizes the topoisomerase II-DNA covalent complexes formed in an intermediate step of the isomerization reaction. The location of the sites of formation of these complexes and their relative strength were studied in vitro using pBR322. Sequences alignment of the regions containing the 24 detectable sites allows to identify GCCGGC-(N)α-TGAC with 9 ⩽ α ⩽ 25 as the DNA sequence recognized by topoisomerase II to form a cleavable complex. Changes in the last two nucleotides of the sequence determine weaker complexes." @default.
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- W1978220613 date "1988-03-01" @default.
- W1978220613 modified "2023-10-18" @default.
- W1978220613 title "Pattern of recognition of DNA by mammalian DNA topoisomerase II" @default.
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- W1978220613 doi "https://doi.org/10.1016/s0006-291x(88)80498-4" @default.
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