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- W1978224954 abstract "Neuronal membrane components that bind alpha-bungarotoxin with high affinity can increase intracellular levels of free calcium, demonstrating the components function as nicotinic receptors. Though such receptors often contain the alpha 7 gene product, which by itself can produce ionotropic receptors in Xenopus oocytes, numerous attempts have failed to demonstrate an ion channel function for the native receptors on neurons. Using rapid application of agonist, we show here that the native receptors are ligand-gated ion channels which are cation selective, prefer nicotine over acetylcholine, and rapidly desensitize. Much of the calcium increase caused in neurons by the receptors under physiological conditions appears to result from their depolarizing the membrane sufficiently to trigger calcium influx through voltage-gated channels." @default.
- W1978224954 created "2016-06-24" @default.
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- W1978224954 date "1994-01-01" @default.
- W1978224954 modified "2023-10-13" @default.
- W1978224954 title "Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels" @default.
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- W1978224954 doi "https://doi.org/10.1016/0896-6273(94)90161-9" @default.
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