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- W1978228253 abstract "Effect of host-mediating anti-tumor drugs, OK-432 and PSK, on hepatic δ-aminolevulinic acid synthetase (ALA synthetase) and heme oxy genase activity was examined. Both OK-432 and PSK were shown to inhibit ALA synthetase activity when administered in vivo to mice. Both OK-432 and PSK also inhibited the 3,5-dicarboethoxy-1,4-dihydro collidine (DDC)-mediated induction of ALA synthetase when administered 12 and 16 h prior to the inducer. Additionally, the administration of OK-432 and PSK resulted in a significant increase in hepatic heme oxy genase activity. These data suggest that the decrease of hepatic drug-metabolizing enzymes as well as cytochrome P-450 levels seen on the administration of OK-432 and PSK is the result of the inhibition of ALA synthetase and of the increase of heme oxygenase activity leading to a decreased heme moiety required for the synthesis of cytochrome P-450 in the liver." @default.
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- W1978228253 date "1978-08-01" @default.
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- W1978228253 title "Effect of host-mediating anti-tumor drugs on hepatic δ-aminolevulinic acid synthetase and heme oxygenase activity in mice" @default.
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- W1978228253 doi "https://doi.org/10.1016/0378-4274(78)90085-1" @default.
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