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• W1978231615 endingPage "351" @default.
• W1978231615 startingPage "337" @default.
• W1978231615 abstract "The extracellularly-responsive kinase (ERK) subfamily of mitogen-activated protein kinases (MAPKs) has been implicated in the regulation of cell growth and differentiation. Activation of ERKs involves a two-step protein kinase cascade lying upstream from ERK, in which the Raf family are the MAPK kinase kinases and the MEK1/MEK2 isoforms are the MAPK kinases. The linear sequence of Raf --> MEK --> ERK constitutes the ERK cascade. Although the ERK cascade is activated through growth factor-regulated receptor protein tyrosine kinases, they are also modulated through G protein-coupled receptors (GPCRs). All four G protein subfamilies (Gq/11 Gi/o, Gs and G12/13) influence the activation state of ERKs. In this review, we describe the ERK cascade and characteristics of its activation through GPCRs. We also discuss the identity of the intervening steps that may couple agonist binding at GPCRs to activation of the ERK cascade." @default.
• W1978231615 created "2016-06-24" @default.
• W1978231615 creator A5036648065 @default.
• W1978231615 creator A5054676735 @default.
• W1978231615 date "1997-08-01" @default.
• W1978231615 modified "2023-10-14" @default.
• W1978231615 title "Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors" @default.
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