FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978233255> ?p ?o ?g. }

• W1978233255 endingPage "47" @default.
• W1978233255 startingPage "37" @default.
• W1978233255 abstract "The interaction between leukocytes and the vascular endothelial cells (EC) via cellular adhesion molecules plays an important role in various inflammatory and immune diseases. It has been suggested that peroxisome proliferator-activated receptor-gamma (PPAR-gamma, a member of the nuclear receptor superfamily of transcription factors) might be involved in the control of inflammation and in modulating the expression of various cytokines. The aim of this investigation was to evaluate the anti-inflammatory properties of PPAR-gamma activators, as well as the inhibitory effect of PPAR-gamma on the expression of adhesion molecules on leukocytes and vascular endothelial cells. Pioglitazone, a synthetic PPAR-gamma activator, suppressed the increase of CD11b/CD18 expression on FMLP-activated leukocytes, as detected by immunofluorescence flow cytometry. However, the FMLP-induced elevation of cytosolic Ca2+ in leukocytes was not suppressed by pioglitazone. Pioglitazone inhibited the expression of VCAM-1 protein and mRNA on activated human umbilical vein endothelial cells (HUVEC) after IL-1beta stimulation, as detected by ELISA and real-time PCR. However, it showed little effect on the expression of ICAM-1 and E-selectin. The present study revealed that pioglitazone can influence monocyte-EC binding by inhibiting VCAM-1 expression on activated EC and neutrophil-EC binding by inhibiting upregulation of CD11b/CD18 on activated neutrophils. Accordingly, pioglitazone may be useful for treating inflammatory diseases." @default.
• W1978233255 created "2016-06-24" @default.
• W1978233255 creator A5004264979 @default.
• W1978233255 creator A5026820334 @default.
• W1978233255 creator A5043728499 @default.
• W1978233255 creator A5050875751 @default.
• W1978233255 creator A5052003452 @default.
• W1978233255 creator A5061869584 @default.
• W1978233255 creator A5067676082 @default.
• W1978233255 creator A5072354499 @default.
• W1978233255 creator A5084648926 @default.
• W1978233255 date "2004-01-01" @default.
• W1978233255 modified "2023-10-16" @default.
• W1978233255 title "Inhibitory effect of pioglitazone on expression of adhesion molecules on neutrophils and endothelial cells" @default.
• W1978233255 cites W1583731895 @default.
• W1978233255 cites W1633340712 @default.
• W1978233255 cites W1639924204 @default.
• W1978233255 cites W1878937427 @default.
• W1978233255 cites W1966286149 @default.
• W1978233255 cites W1966714249 @default.
• W1978233255 cites W1973443459 @default.
• W1978233255 cites W1976621212 @default.
• W1978233255 cites W1985606388 @default.
• W1978233255 cites W1994212260 @default.
• W1978233255 cites W1996862503 @default.
• W1978233255 cites W1999233620 @default.
• W1978233255 cites W2000693909 @default.
• W1978233255 cites W2005348932 @default.
• W1978233255 cites W2021758696 @default.
• W1978233255 cites W2032494769 @default.
• W1978233255 cites W2035393250 @default.
• W1978233255 cites W2043839906 @default.
• W1978233255 cites W2045725952 @default.
• W1978233255 cites W2052878868 @default.
• W1978233255 cites W2078819079 @default.
• W1978233255 cites W2088430139 @default.
• W1978233255 cites W2102772338 @default.
• W1978233255 cites W2115578401 @default.
• W1978233255 cites W2121886714 @default.
• W1978233255 cites W2135565401 @default.
• W1978233255 cites W2137936645 @default.
• W1978233255 cites W2150557496 @default.
• W1978233255 cites W2153054296 @default.
• W1978233255 cites W2397316750 @default.
• W1978233255 cites W4294216491 @default.
• W1978233255 doi "https://doi.org/10.1002/biof.5520200104" @default.
• W1978233255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15096659" @default.
• W1978233255 hasPublicationYear "2004" @default.
• W1978233255 type Work @default.
• W1978233255 sameAs 1978233255 @default.
• W1978233255 citedByCount "50" @default.
• W1978233255 countsByYear W19782332552012 @default.
• W1978233255 countsByYear W19782332552013 @default.
• W1978233255 countsByYear W19782332552016 @default.
• W1978233255 countsByYear W19782332552017 @default.
• W1978233255 countsByYear W19782332552018 @default.
• W1978233255 countsByYear W19782332552019 @default.
• W1978233255 countsByYear W19782332552021 @default.
• W1978233255 countsByYear W19782332552022 @default.
• W1978233255 crossrefType "journal-article" @default.
• W1978233255 hasAuthorship W1978233255A5004264979 @default.
• W1978233255 hasAuthorship W1978233255A5026820334 @default.
• W1978233255 hasAuthorship W1978233255A5043728499 @default.
• W1978233255 hasAuthorship W1978233255A5050875751 @default.
• W1978233255 hasAuthorship W1978233255A5052003452 @default.
• W1978233255 hasAuthorship W1978233255A5061869584 @default.
• W1978233255 hasAuthorship W1978233255A5067676082 @default.
• W1978233255 hasAuthorship W1978233255A5072354499 @default.
• W1978233255 hasAuthorship W1978233255A5084648926 @default.
• W1978233255 hasConcept C134018914 @default.
• W1978233255 hasConcept C153911025 @default.
• W1978233255 hasConcept C16224149 @default.
• W1978233255 hasConcept C170493617 @default.
• W1978233255 hasConcept C171779818 @default.
• W1978233255 hasConcept C185592680 @default.
• W1978233255 hasConcept C187345961 @default.
• W1978233255 hasConcept C202751555 @default.
• W1978233255 hasConcept C203014093 @default.
• W1978233255 hasConcept C2776914184 @default.
• W1978233255 hasConcept C2777180221 @default.
• W1978233255 hasConcept C2777411675 @default.
• W1978233255 hasConcept C2778384471 @default.
• W1978233255 hasConcept C53122370 @default.
• W1978233255 hasConcept C55493867 @default.
• W1978233255 hasConcept C555293320 @default.
• W1978233255 hasConcept C86803240 @default.
• W1978233255 hasConcept C95444343 @default.
• W1978233255 hasConceptScore W1978233255C134018914 @default.
• W1978233255 hasConceptScore W1978233255C153911025 @default.
• W1978233255 hasConceptScore W1978233255C16224149 @default.
• W1978233255 hasConceptScore W1978233255C170493617 @default.
• W1978233255 hasConceptScore W1978233255C171779818 @default.
• W1978233255 hasConceptScore W1978233255C185592680 @default.
• W1978233255 hasConceptScore W1978233255C187345961 @default.
• W1978233255 hasConceptScore W1978233255C202751555 @default.
• W1978233255 hasConceptScore W1978233255C203014093 @default.
• W1978233255 hasConceptScore W1978233255C2776914184 @default.
• W1978233255 hasConceptScore W1978233255C2777180221 @default.

• next