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• W1978236018 abstract "The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid. Instead, the paratope of the antibody undergoes a large conformational change to accommodate the epitope. Unlike any previously described antibody-antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface. Fab17-IA penetrates deep within the canyon in which the cellular receptor for HRV-14 binds. Hence, it is unlikely that viral quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably dictates receptor binding and subsequent uncoating events and has little or no influence on concealing the virus from the immune system." @default.
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• W1978236018 date "1996-09-01" @default.
• W1978236018 modified "2023-10-13" @default.
• W1978236018 title "Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon" @default.
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• W1978236018 doi "https://doi.org/10.1038/383350a0" @default.
• W1978236018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4167671" @default.
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