Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978237352> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1978237352 abstract "This issue of the Journal ofMolecularMedicine contains three outstanding review articles that summarize recent advances in cancer metastasis and anti-angiogenic therapy by leaders in the field. Interactions between cancer cells and stromal cells play critical roles in the metastatic process, which in turn is the major cause of cancer mortality. Among the stromal cell types that are discussed in these review articles are cancer-associated fibroblasts, inflammatory cells, and endothelial cells. Smith and Kang review the rapidly growing body of data regarding the mechanisms by which many different inflammatory cell types, including macrophages, myeloid-derived suppressor cells, neutrophils, regulatory T cells, and suppressive dendritic cells, are recruited to primary tumors and promote metastasis [1]. In addition, factors secreted by primary tumors also recruit bone marrow-derived cells to future sites of metastasis in the lungs and other organs, as part of the process known as pre-metastatic niche formation. Kahlert and Kalluri review the role of exosomes in cancer progression and metastasis [2]. Exosomes are membrane vesicle nanoparticles containing proteins, mRNAs, and microRNAs that are released by cancer cells and change the biological properties of stromal cells to support cancer progression. The potential use of exosomes as biomarkers in cancer diagnosis and therapy is also discussed. One of the unfulfilled promises of cancer research over the last decade has been the targeting of tumor angiogenesis for cancer therapy. Verma and colleagues review the multiple mechanisms by which glioblastoma multiforme, which is a highly vascularized and invasive brain cancer, becomes resistant to anti-angiogenic therapy [3]. They also discuss the mechanisms by which treatment with angiogenesis inhibitors may promote invasive properties of cancer cells. Taken together, these three reviews highlight the increasing complexity of cancer biology. One consequence of this complexity is an appreciation that successful therapy will require combinations of drugs that reduce the probability of resistance or counter-therapeutic effects and that target both cancer and stromal cell populations." @default.
- W1978237352 created "2016-06-24" @default.
- W1978237352 creator A5051276665 @default.
- W1978237352 date "2013-03-21" @default.
- W1978237352 modified "2023-09-28" @default.
- W1978237352 title "Advances in cancer biology and therapy" @default.
- W1978237352 cites W1969607893 @default.
- W1978237352 cites W1994374087 @default.
- W1978237352 cites W2030028321 @default.
- W1978237352 doi "https://doi.org/10.1007/s00109-013-1024-2" @default.
- W1978237352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23515622" @default.
- W1978237352 hasPublicationYear "2013" @default.
- W1978237352 type Work @default.
- W1978237352 sameAs 1978237352 @default.
- W1978237352 citedByCount "5" @default.
- W1978237352 countsByYear W19782373522013 @default.
- W1978237352 countsByYear W19782373522014 @default.
- W1978237352 countsByYear W19782373522016 @default.
- W1978237352 countsByYear W19782373522017 @default.
- W1978237352 countsByYear W19782373522021 @default.
- W1978237352 crossrefType "journal-article" @default.
- W1978237352 hasAuthorship W1978237352A5051276665 @default.
- W1978237352 hasBestOaLocation W19782373521 @default.
- W1978237352 hasConcept C104317684 @default.
- W1978237352 hasConcept C121608353 @default.
- W1978237352 hasConcept C126322002 @default.
- W1978237352 hasConcept C145059251 @default.
- W1978237352 hasConcept C16930146 @default.
- W1978237352 hasConcept C203014093 @default.
- W1978237352 hasConcept C20518536 @default.
- W1978237352 hasConcept C2779013556 @default.
- W1978237352 hasConcept C2780394083 @default.
- W1978237352 hasConcept C502942594 @default.
- W1978237352 hasConcept C55427017 @default.
- W1978237352 hasConcept C55493867 @default.
- W1978237352 hasConcept C71924100 @default.
- W1978237352 hasConcept C86803240 @default.
- W1978237352 hasConcept C96232424 @default.
- W1978237352 hasConceptScore W1978237352C104317684 @default.
- W1978237352 hasConceptScore W1978237352C121608353 @default.
- W1978237352 hasConceptScore W1978237352C126322002 @default.
- W1978237352 hasConceptScore W1978237352C145059251 @default.
- W1978237352 hasConceptScore W1978237352C16930146 @default.
- W1978237352 hasConceptScore W1978237352C203014093 @default.
- W1978237352 hasConceptScore W1978237352C20518536 @default.
- W1978237352 hasConceptScore W1978237352C2779013556 @default.
- W1978237352 hasConceptScore W1978237352C2780394083 @default.
- W1978237352 hasConceptScore W1978237352C502942594 @default.
- W1978237352 hasConceptScore W1978237352C55427017 @default.
- W1978237352 hasConceptScore W1978237352C55493867 @default.
- W1978237352 hasConceptScore W1978237352C71924100 @default.
- W1978237352 hasConceptScore W1978237352C86803240 @default.
- W1978237352 hasConceptScore W1978237352C96232424 @default.
- W1978237352 hasLocation W19782373521 @default.
- W1978237352 hasLocation W19782373522 @default.
- W1978237352 hasOpenAccess W1978237352 @default.
- W1978237352 hasPrimaryLocation W19782373521 @default.
- W1978237352 hasRelatedWork W1993896796 @default.
- W1978237352 hasRelatedWork W2110342205 @default.
- W1978237352 hasRelatedWork W2147083075 @default.
- W1978237352 hasRelatedWork W2256034989 @default.
- W1978237352 hasRelatedWork W2294005449 @default.
- W1978237352 hasRelatedWork W2463619128 @default.
- W1978237352 hasRelatedWork W2465082602 @default.
- W1978237352 hasRelatedWork W2467302424 @default.
- W1978237352 hasRelatedWork W2779072275 @default.
- W1978237352 hasRelatedWork W2802755724 @default.
- W1978237352 hasRelatedWork W2884666363 @default.
- W1978237352 hasRelatedWork W2899414628 @default.
- W1978237352 hasRelatedWork W2940174050 @default.
- W1978237352 hasRelatedWork W2969431439 @default.
- W1978237352 hasRelatedWork W3097155613 @default.
- W1978237352 hasRelatedWork W3145609012 @default.
- W1978237352 hasRelatedWork W3162665122 @default.
- W1978237352 hasRelatedWork W3173411349 @default.
- W1978237352 hasRelatedWork W3203998457 @default.
- W1978237352 hasRelatedWork W3210567878 @default.
- W1978237352 isParatext "false" @default.
- W1978237352 isRetracted "false" @default.
- W1978237352 magId "1978237352" @default.
- W1978237352 workType "article" @default.