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- W1978239531 endingPage "5174" @default.
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- W1978239531 abstract "Tissue-type plasminogen activator (tPA) is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. However, emerging evidence indicates that tPA also functions as a cytokine that transmits its signal across the cell membrane, initiates a diverse array of intracellular signaling, and dictates gene expression in the nuclei. tPA binds to the cell membrane LDL receptor-related protein 1 (LRP-1), triggers its tyrosine phosphorylation. As a cytokine, tPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. It facilitates tubular epithelial to mesenchymal transition, potentiates myofibroblast activation, and protects renal interstitial fibroblasts/myofibroblasts from apoptosis. Together, growing evidence has implicated tPA as a fibrogenic cytokine that promotes the progression of kidney diseases. These new findings have radically changed our conception of tPA in renal fibrogenesis and represent a paradigm shift towards uncovering its cytokine function." @default.
- W1978239531 created "2016-06-24" @default.
- W1978239531 creator A5066262973 @default.
- W1978239531 date "2008-01-01" @default.
- W1978239531 modified "2023-10-15" @default.
- W1978239531 title "Novel actions of tissue-type plasminogen activator in chronic kidney disease" @default.
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- W1978239531 doi "https://doi.org/10.2741/3073" @default.
- W1978239531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650246" @default.
- W1978239531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18508579" @default.
- W1978239531 hasPublicationYear "2008" @default.
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