FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978245176> ?p ?o ?g. }

• W1978245176 endingPage "390" @default.
• W1978245176 startingPage "377" @default.
• W1978245176 abstract "The management of nursing home-acquired pneumonia (NHAP) continues to be debatable because of the lack of clinical trials and controversy regarding its aetiology. The controversy regarding aetiology stems, in part, from studies that utilised sputum cultures for the diagnosis of NHAP without assessing the quality of the samples. These studies found a high proportion of Gram-negative aerobic bacilli in cultures as well as Staphylococcus aureus. However, in studies that have assessed the reliability of sputum samples, Gram-negative bacilli and S. aureus were isolated infrequently and Streptococcus pneumoniae and Haemophilus influenzae isolated most commonly. Since Gram-negative aerobic bacilli and S. aureus frequently cause hospital-acquired pneumonia, some authors have considered NHAP to be a variant of this group. Many other studies, however, have considered NHAP as part of the community-acquired pneumonia category. Depending on which categorisation is used for NHAP, the treatment recommendations have varied. There are several factors to consider in the management of NHAP in addition to choice of antibacterial: hospitalisation decision, initial route of administration of antibacterials for treatment in the nursing home, timing of switch from a parenteral to an oral agent and the duration of therapy. These factors, which have not been addressed in published guidelines, are discussed in this review. Recent guidelines recommend a fluoroquinolone (gatifloxacin, levofloxacin or moxifloxacin) or amoxicillin/clavulanic acid plus a macrolide for initial treatment of NHAP in the nursing home. For treatment in the hospital, a parenteral fluoroquinolone (as listed above) or a second- or third-generation cephalosporin plus a macrolide is recommended. A recent guideline for the treatment of healthcare-associated pneumonia (that includes NHAP) recommended an antipseudomonal cephalosporin or a carbapenem or an antipseudomonal penicillin/β-lactamase inhibitor plus ciprofloxacin plus vancomycin or linezolid for treatment of NHAP based on findings in residents with severe pneumonia who required mechanical ventilation. However, this recommendation does not apply to the majority of residents who are hospitalised with pneumonia and not intubated. Other factors to consider when choosing an empiric regimen include recent antibacterial therapy and prior colonisation with a resistant organism, e.g. methicillin-resistant S. aureus. Recently, a group of studies by investigators in The Netherlands have focused on the concept of withholding antibacterial therapy in nursing home residents with pneumonia who have advanced dementia. These studies are reviewed in some detail because this is an approach to the management of NHAP that is uncommon but deserves more consideration given the terminal status of these people. Future studies of NHAP should focus on development of rapid (molecular) methods to identify aetiological agents, determination of the optimum antimicrobial regimen and duration of therapy, and identification of criteria that can assist physicians and families in making the decision to withhold antimicrobial therapy in residents with advanced dementia and pneumonia." @default.
• W1978245176 created "2016-06-24" @default.
• W1978245176 creator A5051082712 @default.
• W1978245176 date "2006-01-01" @default.
• W1978245176 modified "2023-10-10" @default.
• W1978245176 title "Nursing Home-Acquired Pneumonia" @default.
• W1978245176 cites W119794492 @default.
• W1978245176 cites W142259135 @default.
• W1978245176 cites W1482360300 @default.
• W1978245176 cites W1560068734 @default.
• W1978245176 cites W175385783 @default.
• W1978245176 cites W1963710404 @default.
• W1978245176 cites W1969521541 @default.
• W1978245176 cites W1972194401 @default.
• W1978245176 cites W1974540201 @default.
• W1978245176 cites W1981064346 @default.
• W1978245176 cites W1981621343 @default.
• W1978245176 cites W1983161254 @default.
• W1978245176 cites W1983983286 @default.
• W1978245176 cites W1989889776 @default.
• W1978245176 cites W1994041199 @default.
• W1978245176 cites W1995231765 @default.
• W1978245176 cites W1996306145 @default.
• W1978245176 cites W2017407448 @default.
• W1978245176 cites W2020852366 @default.
• W1978245176 cites W2023341188 @default.
• W1978245176 cites W2024859628 @default.
• W1978245176 cites W2027162482 @default.
• W1978245176 cites W2031225383 @default.
• W1978245176 cites W2035760184 @default.
• W1978245176 cites W2041687951 @default.
• W1978245176 cites W2044010050 @default.
• W1978245176 cites W2046949207 @default.
• W1978245176 cites W2052915152 @default.
• W1978245176 cites W2052966071 @default.
• W1978245176 cites W2053033354 @default.
• W1978245176 cites W2054189676 @default.
• W1978245176 cites W2058297096 @default.
• W1978245176 cites W2058299548 @default.
• W1978245176 cites W2064595357 @default.
• W1978245176 cites W2073919046 @default.
• W1978245176 cites W2075124201 @default.
• W1978245176 cites W2075984383 @default.
• W1978245176 cites W2077792112 @default.
• W1978245176 cites W2083415558 @default.
• W1978245176 cites W2084550262 @default.
• W1978245176 cites W2091953741 @default.
• W1978245176 cites W2094460420 @default.
• W1978245176 cites W2096903918 @default.
• W1978245176 cites W2100666674 @default.
• W1978245176 cites W2103258561 @default.
• W1978245176 cites W2112302527 @default.
• W1978245176 cites W2116117562 @default.
• W1978245176 cites W2117397026 @default.
• W1978245176 cites W2121354747 @default.
• W1978245176 cites W2122012295 @default.
• W1978245176 cites W2123071011 @default.
• W1978245176 cites W2123324969 @default.
• W1978245176 cites W2131768154 @default.
• W1978245176 cites W2140087978 @default.
• W1978245176 cites W2142191165 @default.
• W1978245176 cites W2142230428 @default.
• W1978245176 cites W2142622691 @default.
• W1978245176 cites W2145774197 @default.
• W1978245176 cites W2150078610 @default.
• W1978245176 cites W2158075347 @default.
• W1978245176 cites W2159332114 @default.
• W1978245176 cites W2160207876 @default.
• W1978245176 cites W2165572309 @default.
• W1978245176 cites W2171405214 @default.
• W1978245176 cites W2320270386 @default.
• W1978245176 cites W2321881523 @default.
• W1978245176 cites W2326979296 @default.
• W1978245176 cites W2498497275 @default.
• W1978245176 cites W4206060316 @default.
• W1978245176 cites W4211194064 @default.
• W1978245176 cites W4290746977 @default.
• W1978245176 cites W61535552 @default.
• W1978245176 doi "https://doi.org/10.2165/00002512-200623050-00002" @default.
• W1978245176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16823991" @default.
• W1978245176 hasPublicationYear "2006" @default.
• W1978245176 type Work @default.
• W1978245176 sameAs 1978245176 @default.
• W1978245176 citedByCount "21" @default.
• W1978245176 countsByYear W19782451762013 @default.
• W1978245176 countsByYear W19782451762014 @default.
• W1978245176 countsByYear W19782451762015 @default.
• W1978245176 countsByYear W19782451762018 @default.
• W1978245176 countsByYear W19782451762020 @default.
• W1978245176 crossrefType "journal-article" @default.
• W1978245176 hasAuthorship W1978245176A5051082712 @default.
• W1978245176 hasBestOaLocation W19782451761 @default.
• W1978245176 hasConcept C126322002 @default.
• W1978245176 hasConcept C142724271 @default.
• W1978245176 hasConcept C177713679 @default.
• W1978245176 hasConcept C2776301714 @default.
• W1978245176 hasConcept C2777914695 @default.
• W1978245176 hasConcept C2778836808 @default.

• next