FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978250526> ?p ?o ?g. }

• W1978250526 endingPage "956" @default.
• W1978250526 startingPage "952" @default.
• W1978250526 abstract "Oxymetazoline nasal spray is not FDA approved for use in children less than 6 years; however, its safety and efficacy are widely accepted, and it is in widespread use in children prior to procedures that may lead to epistaxis. We report a case of intraoperative oxymetazoline toxicity in a 4-year-old boy that led to a hypertensive crisis. While examining the possible causes for this problem, we became aware that the method of drug delivery led to an unanticipated overdose. The position in which the bottle is held causes pronounced variation in the quantity of oxymetazoline dispensed.To examine the impact that bottle position has on the volume delivered, we measured the volume of oxymetazoline dispensed with the bottle in the upright and inverted position. We also measured the volume of a drop of oxymetazoline dispensed from the bottle. Because an additional source of oxymetazoline exposure is from packing the nares with surgical pledgets, we analyzed the volume of oxymetazoline absorbed by each pledget.Squeezing the bottle in the upright position results in a fine spray of fluid that averaged 28.9 ± 6.8 μl and was largely independent of effort. This volume is nearly identical to the measured volume of a drop of oxymetazoline, which was 30 μl. However, squeezing the bottle in the inverted position resulted in a steady stream of fluid, and the volume administered was completely effort dependent. Multiple tests in the inverted position demonstrated an average volume of 1037 ± 527 μl, with a range of 473-2196 μl. Lastly, the volume of oxymetazoline absorbed by each surgical pledget was 1511 ± 184 μl.Our testing indicates that bottle position during oxymetazoline administration can cause up to a 75-fold increase in intended drug administration." @default.
• W1978250526 created "2016-06-24" @default.
• W1978250526 creator A5016240335 @default.
• W1978250526 creator A5032757652 @default.
• W1978250526 date "2013-05-16" @default.
• W1978250526 modified "2023-10-02" @default.
• W1978250526 title "Oxymetazoline and hypertensive crisis in a child: can we prevent it?" @default.
• W1978250526 cites W1973376756 @default.
• W1978250526 cites W1975085838 @default.
• W1978250526 cites W1980830305 @default.
• W1978250526 cites W1981537050 @default.
• W1978250526 cites W1999920946 @default.
• W1978250526 cites W2016238095 @default.
• W1978250526 cites W2020425716 @default.
• W1978250526 cites W2037292456 @default.
• W1978250526 cites W2056690319 @default.
• W1978250526 cites W2066193498 @default.
• W1978250526 cites W2075634596 @default.
• W1978250526 cites W2075718169 @default.
• W1978250526 cites W2077065294 @default.
• W1978250526 cites W2078571359 @default.
• W1978250526 cites W2080426114 @default.
• W1978250526 cites W2081556953 @default.
• W1978250526 cites W2083550041 @default.
• W1978250526 cites W2088205806 @default.
• W1978250526 cites W2101108983 @default.
• W1978250526 cites W2115187732 @default.
• W1978250526 cites W2117324379 @default.
• W1978250526 cites W2150478264 @default.
• W1978250526 cites W2155788147 @default.
• W1978250526 cites W2156912958 @default.
• W1978250526 cites W2161387541 @default.
• W1978250526 cites W2170284108 @default.
• W1978250526 doi "https://doi.org/10.1111/pan.12192" @default.
• W1978250526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23679077" @default.
• W1978250526 hasPublicationYear "2013" @default.
• W1978250526 type Work @default.
• W1978250526 sameAs 1978250526 @default.
• W1978250526 citedByCount "23" @default.
• W1978250526 countsByYear W19782505262013 @default.
• W1978250526 countsByYear W19782505262014 @default.
• W1978250526 countsByYear W19782505262015 @default.
• W1978250526 countsByYear W19782505262016 @default.
• W1978250526 countsByYear W19782505262017 @default.
• W1978250526 countsByYear W19782505262018 @default.
• W1978250526 countsByYear W19782505262019 @default.
• W1978250526 countsByYear W19782505262020 @default.
• W1978250526 countsByYear W19782505262021 @default.
• W1978250526 countsByYear W19782505262022 @default.
• W1978250526 countsByYear W19782505262023 @default.
• W1978250526 crossrefType "journal-article" @default.
• W1978250526 hasAuthorship W1978250526A5016240335 @default.
• W1978250526 hasAuthorship W1978250526A5032757652 @default.
• W1978250526 hasConcept C121332964 @default.
• W1978250526 hasConcept C126322002 @default.
• W1978250526 hasConcept C159985019 @default.
• W1978250526 hasConcept C170493617 @default.
• W1978250526 hasConcept C192562407 @default.
• W1978250526 hasConcept C20556612 @default.
• W1978250526 hasConcept C2780042274 @default.
• W1978250526 hasConcept C2910477827 @default.
• W1978250526 hasConcept C32236832 @default.
• W1978250526 hasConcept C40465926 @default.
• W1978250526 hasConcept C42219234 @default.
• W1978250526 hasConcept C62520636 @default.
• W1978250526 hasConcept C71924100 @default.
• W1978250526 hasConceptScore W1978250526C121332964 @default.
• W1978250526 hasConceptScore W1978250526C126322002 @default.
• W1978250526 hasConceptScore W1978250526C159985019 @default.
• W1978250526 hasConceptScore W1978250526C170493617 @default.
• W1978250526 hasConceptScore W1978250526C192562407 @default.
• W1978250526 hasConceptScore W1978250526C20556612 @default.
• W1978250526 hasConceptScore W1978250526C2780042274 @default.
• W1978250526 hasConceptScore W1978250526C2910477827 @default.
• W1978250526 hasConceptScore W1978250526C32236832 @default.
• W1978250526 hasConceptScore W1978250526C40465926 @default.
• W1978250526 hasConceptScore W1978250526C42219234 @default.
• W1978250526 hasConceptScore W1978250526C62520636 @default.
• W1978250526 hasConceptScore W1978250526C71924100 @default.
• W1978250526 hasIssue "10" @default.
• W1978250526 hasLocation W19782505261 @default.
• W1978250526 hasLocation W19782505262 @default.
• W1978250526 hasOpenAccess W1978250526 @default.
• W1978250526 hasPrimaryLocation W19782505261 @default.
• W1978250526 hasRelatedWork W1978250526 @default.
• W1978250526 hasRelatedWork W2046557097 @default.
• W1978250526 hasRelatedWork W2050344269 @default.
• W1978250526 hasRelatedWork W2066470225 @default.
• W1978250526 hasRelatedWork W2070632567 @default.
• W1978250526 hasRelatedWork W2090680924 @default.
• W1978250526 hasRelatedWork W2151613568 @default.
• W1978250526 hasRelatedWork W2227757951 @default.
• W1978250526 hasRelatedWork W2410032126 @default.
• W1978250526 hasRelatedWork W2507109544 @default.
• W1978250526 hasVolume "23" @default.
• W1978250526 isParatext "false" @default.
• W1978250526 isRetracted "false" @default.
• W1978250526 magId "1978250526" @default.

• next