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• W1978255802 endingPage "1449" @default.
• W1978255802 startingPage "1444" @default.
• W1978255802 abstract "To examine the effects of the cAMP-independent protein kinase-C system and interleukin-1 (IL-1) on secretion of ACTH and POMC gene expression in cultured rat anterior pituitary (AP) cells, AP cells were incubated with CRF, 8-bromo-cAMP, arginine vasopressin, angiotensin II, norepinephrine, and phorbol 12-myristate 13-acetate. After 15 h of incubation, CRF and 8-bromo-cAMP increased both ACTH release and the POMC mRNA level. Arginine vasopressin, angiotensin II, norepinephrine, or phorbol 12-myristate 13-acetate stimulated ACTH release but failed to increase basal or CRFstimulated POMC mRNA levels. Human recombinant IL-lα and -β increased neither ACTH release nor POMC mRNA levels after 3 h of incubation. After 15 h of incubation, 100 pM to 10 nM IL-lα and -β increased ACTH release. However, POMC mRNA levels were significantly elevated only by 10 pM IL-1β. These results suggest that the CRF-cAMP system plays a major role in both ACTH release and expression of the POMC gene in AP cells, but the cAMP-independent protein kinase-C system contributes only to ACTH release; that acute stimulation of ACTH release from AP with IL-1 administration is not due to direct action of IL-1 at the pituitary level; that chronic exposure of AP cells to IL-lα or -β can stimulate ACTH release; and that the direct effects of IL-lα and -β on POMC gene expression, if any, seem to be minimal. (Endocrinology124: 1444-1449,1989)" @default.
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• W1978255802 date "1989-03-01" @default.
• W1978255802 modified "2023-10-15" @default.
• W1978255802 title "Effects of Protein Kinase-C-Related Adrenocorticotropin Secretagogues and Interleukin-1 on Proopiomelanocortin Gene Expression in Rat Anterior Pituitary Cells*" @default.
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• W1978255802 doi "https://doi.org/10.1210/endo-124-3-1444" @default.
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