FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978255992> ?p ?o ?g. }

• W1978255992 abstract "Introduction of antiretroviral therapy (ART) in sub-Saharan Africa was a hot debate due to many concerns about adherence, logistics and resistance. Currently, it has been significantly scaled up. However as the WHO clinico-immunological approaches for initiation and monitoring of ART in the region lacks viral load determination and drug resistance monitoring, HIV infected adults and children may be at risk for unrecognized virologic failure and the subsequent development of antiretroviral drug resistance. This study evaluates the virological efficacy and immunological recovery of HIV/AIDS patients under ART.Consecutive HIV-1 infected adults (N = 100) and children (N = 100) who have been receiving ART for up to 6 years at Gondar University Hospital, Ethiopia were enrolled following the WHO protocol for assessment of acquired drug resistance. Magnitude of viral suppression, genotypic drug resistance mutations and patterns of CD4+ T cell recovery were determined using standard virological and immunological methods.Virological suppression (HIV RNA < 40 copies/ml) was observed in 82 and 87% of adults and children on a median time of 24 months on ART, respectively. Mutation K103N conferring resistance to non nucleoside reverse transcriptase inhibitors and thymidine analogue mutations (M41L, L210W) were found only in one adult and child patient, respectively. Median CD4+ T cell count has increased from baseline 124 to 266 (IQR: 203-306) and 345 (IQR: 17-1435) to 998 (IQR: 678-2205) cells/mm3 in adults and children respectively after 12 months of ART. Nevertheless, small but significant number of clinically asymptomatic adults (16%) and children (13%) had low level viraemia (HIV-1 RNA 41-1000 copies/ml).Majority of both adults (82%) and children (87%) who received ART showed high viral suppression and immunological recovery. This indicates that despite limited resources in the setting virological efficacy can be sustained for a substantial length of time and also enhance immunological recovery irrespective of age. However, the presence of drug resistance mutations and low level viraemia among clinically asymptomatic patients highlights the need for virological monitoring." @default.
• W1978255992 created "2016-06-24" @default.
• W1978255992 creator A5010190814 @default.
• W1978255992 creator A5039206168 @default.
• W1978255992 creator A5088343134 @default.
• W1978255992 date "2014-01-14" @default.
• W1978255992 modified "2023-10-10" @default.
• W1978255992 title "Virological efficacy and immunological recovery among Ethiopian HIV-1 infected adults and children" @default.
• W1978255992 cites W1889532030 @default.
• W1978255992 cites W1972935005 @default.
• W1978255992 cites W1986097902 @default.
• W1978255992 cites W2001017566 @default.
• W1978255992 cites W2019065964 @default.
• W1978255992 cites W2027974789 @default.
• W1978255992 cites W2032039529 @default.
• W1978255992 cites W2032952072 @default.
• W1978255992 cites W2034659049 @default.
• W1978255992 cites W2036122622 @default.
• W1978255992 cites W2043176798 @default.
• W1978255992 cites W2046834121 @default.
• W1978255992 cites W2068948840 @default.
• W1978255992 cites W2080559943 @default.
• W1978255992 cites W2081206618 @default.
• W1978255992 cites W2086310869 @default.
• W1978255992 cites W2098883581 @default.
• W1978255992 cites W2100049335 @default.
• W1978255992 cites W2102741140 @default.
• W1978255992 cites W2103920597 @default.
• W1978255992 cites W2116758166 @default.
• W1978255992 cites W2121668497 @default.
• W1978255992 cites W2144361427 @default.
• W1978255992 cites W2146634980 @default.
• W1978255992 cites W2149573022 @default.
• W1978255992 cites W2153370925 @default.
• W1978255992 cites W2154729256 @default.
• W1978255992 cites W2158842834 @default.
• W1978255992 cites W2159955764 @default.
• W1978255992 cites W2167354451 @default.
• W1978255992 cites W2171197540 @default.
• W1978255992 cites W2172274075 @default.
• W1978255992 cites W2187955543 @default.
• W1978255992 doi "https://doi.org/10.1186/1471-2334-14-28" @default.
• W1978255992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3900473" @default.
• W1978255992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24422906" @default.
• W1978255992 hasPublicationYear "2014" @default.
• W1978255992 type Work @default.
• W1978255992 sameAs 1978255992 @default.
• W1978255992 citedByCount "36" @default.
• W1978255992 countsByYear W19782559922014 @default.
• W1978255992 countsByYear W19782559922015 @default.
• W1978255992 countsByYear W19782559922016 @default.
• W1978255992 countsByYear W19782559922017 @default.
• W1978255992 countsByYear W19782559922018 @default.
• W1978255992 countsByYear W19782559922019 @default.
• W1978255992 countsByYear W19782559922020 @default.
• W1978255992 countsByYear W19782559922021 @default.
• W1978255992 countsByYear W19782559922022 @default.
• W1978255992 countsByYear W19782559922023 @default.
• W1978255992 crossrefType "journal-article" @default.
• W1978255992 hasAuthorship W1978255992A5010190814 @default.
• W1978255992 hasAuthorship W1978255992A5039206168 @default.
• W1978255992 hasAuthorship W1978255992A5088343134 @default.
• W1978255992 hasBestOaLocation W19782559922 @default.
• W1978255992 hasConcept C114851261 @default.
• W1978255992 hasConcept C126322002 @default.
• W1978255992 hasConcept C142462285 @default.
• W1978255992 hasConcept C142724271 @default.
• W1978255992 hasConcept C159047783 @default.
• W1978255992 hasConcept C185032368 @default.
• W1978255992 hasConcept C187212893 @default.
• W1978255992 hasConcept C190139176 @default.
• W1978255992 hasConcept C190612196 @default.
• W1978255992 hasConcept C203014093 @default.
• W1978255992 hasConcept C205545832 @default.
• W1978255992 hasConcept C2777910003 @default.
• W1978255992 hasConcept C2778451633 @default.
• W1978255992 hasConcept C2993143319 @default.
• W1978255992 hasConcept C3013748606 @default.
• W1978255992 hasConcept C71924100 @default.
• W1978255992 hasConcept C86803240 @default.
• W1978255992 hasConcept C89423630 @default.
• W1978255992 hasConceptScore W1978255992C114851261 @default.
• W1978255992 hasConceptScore W1978255992C126322002 @default.
• W1978255992 hasConceptScore W1978255992C142462285 @default.
• W1978255992 hasConceptScore W1978255992C142724271 @default.
• W1978255992 hasConceptScore W1978255992C159047783 @default.
• W1978255992 hasConceptScore W1978255992C185032368 @default.
• W1978255992 hasConceptScore W1978255992C187212893 @default.
• W1978255992 hasConceptScore W1978255992C190139176 @default.
• W1978255992 hasConceptScore W1978255992C190612196 @default.
• W1978255992 hasConceptScore W1978255992C203014093 @default.
• W1978255992 hasConceptScore W1978255992C205545832 @default.
• W1978255992 hasConceptScore W1978255992C2777910003 @default.
• W1978255992 hasConceptScore W1978255992C2778451633 @default.
• W1978255992 hasConceptScore W1978255992C2993143319 @default.
• W1978255992 hasConceptScore W1978255992C3013748606 @default.
• W1978255992 hasConceptScore W1978255992C71924100 @default.
• W1978255992 hasConceptScore W1978255992C86803240 @default.
• W1978255992 hasConceptScore W1978255992C89423630 @default.
• W1978255992 hasIssue "1" @default.

• next