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• W1978257075 abstract "DRw6 has been difficult to define serologically. In the present experiments we have developed T cell lines in order to characterize the components of a DRw6 haplotype. This was accomplished by priming T cells with allogeneic mononuclear cells mismatched for DRw6, Dw6, and MT2. Subsequently, three sublines with distinct reactivity patterns were derived by limiting dilution. The specificities detected by these sublines included: (a) a specificity found on a subset of cells positive for DRw6 which was inhibited by monoclonal antibodies against DS(DC), the human homologue of the murine IA-encoded molecules, (b) another DRw6-associated specificity blocked by an MT2-like antibody, and (c) an MT2-like specificity blocked by monoclonal antibodies reactive with a different MT2-associated determinant. These results show that more than one IE-like, as well as the DS/DC (IA-like) molecules, carry distinctive antigenic epitopes that can be recognized by allogeneic T cells. Primed T cell lines may be useful for a better definition of certain haplotypes which are at present difficult to characterize with serological reagents alone." @default.
• W1978257075 created "2016-06-24" @default.
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• W1978257075 date "1984-12-01" @default.
• W1978257075 modified "2023-09-24" @default.
• W1978257075 title "Different specificities of an HLA-DRw6 haplotype detected by alloreactive T lymphocytes" @default.
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• W1978257075 doi "https://doi.org/10.1016/0198-8859(84)90059-4" @default.
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