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• W1978265572 abstract "Coupling between D-1 dopamine receptors and G proteins in cell lines expressing human D-1 receptors and different G proteins was examined. Pertussis toxin (PTX) treatment of rat pituitary GH⁴C¹ cells significantly reduced, but did not abolish, agonist high affinity binding sites of the D-1 dopamine receptor; in SK-N-MC neuroblastoma cells, PTX failed to have any effect on D-1 high affinity sites. Cholera toxin (CTX) treatment of GH⁴C¹ cells reduced but did not abolish the high affinity sites of D-1 receptors, while in SK-N-MC cells, treatment with CTX abolished all the high affinity sites. Western blot analyses with specific antisera indicated that G^sα, G_i1α, G_i3α, and G^qα were expressed in both cell lines, while G_i2α and G^oα were expressed in GH⁴C¹ but not SK-N-MC cells. Antisera NEI-805 (anti-G^sα) and 9072 (anti-G^oα) immunoprecipitated 24 ± 4.3 and 34.4 ± 6.9%, respectively, of G protein-associated D-1 dopamine receptors. Antisera 3646 (anti-G_i1α), 1521 (anti-G_i2α), 1518 (anti-G_i3α), and 0941 (anti-G^qα) failed to coimmunoprecipitate appreciable levels of soluble receptors. These data indicate that D-1 dopamine receptors are coupled to both G^sα and G^oα but not to G^qα." @default.
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• W1978265572 date "1995-06-01" @default.
• W1978265572 modified "2023-10-17" @default.
• W1978265572 title "Coupling of Human D-1 Dopamine Receptors to Different Guanine Nucleotide Binding Proteins. EVIDENCE THAT D-1 DOPAMINE RECEPTORS CAN COUPLE TO BOTH Gs AND Go" @default.
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• W1978265572 doi "https://doi.org/10.1074/jbc.270.24.14672" @default.
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