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- W1978265637 abstract "Purpose: Changes in respiratory function occurring in the months and years following radiotherapy have been well documented. The changes that occur in the hours after treatment are less clear, we report a study that recorded peak expiratory flow rate (PEFR) in the 72 h following radiotherapy to the mediastinum and large airways. Methods: Fifty-six patients with carcinoma affecting the major bronchii were recruited; 39 were male, with a median age of 66 years; 49 had histologically confirmed lung cancer. The median baseline PEFR was 300 l/s (range: 120–600). Patients were asked to record home PEFR readings in the 72 h that followed the first fraction of radiotherapy. Doses ranges from an 8-Gy single fraction to 60 Gy in 30 fractions. Results: Forty-nine patients recorded a fall in PEFR (3%–60% of the baseline value) in the 24 h after radiotherapy, the mean for all 56 patients was a fall of 20.3% (95% confidence interval −15.8% to −24.8%). These lowest values occurred a median time of 6 h after treatment (range: 2–24 h). By 72 h the mean PEFR had returned to the baseline. Tumour site (central or lobar bronchus) and fraction size (<3 GY or > 3 Gy) had no significant effect on the fall in PEFR (Mann-Whitney U-test P = 0.15 and P = 0.06, respectively). Conclusion: We conclude that a fall in PEFR can occur after radiotherapy treatment to the mediastinum. This is of concern in patients being treated for bronchial carcinoma whose respiratory function may already be compromised." @default.
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- W1978265637 date "1997-07-01" @default.
- W1978265637 modified "2023-10-18" @default.
- W1978265637 title "Acute changes in peak expiratory flow rate following palliative radiotherapy for bronchial carcinoma" @default.
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- W1978265637 doi "https://doi.org/10.1016/s0167-8140(96)01892-0" @default.
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