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- W1978268520 abstract "Abstract The 2′-β-fluoro analogue of 2′,3′-dideoxyguanosine has been prepared by two synthetic routes. This compound and two analogues have anti-HIV activity in at least two of three host cell systems used (ATH8, CEM, PBL). These compounds, as well as their ddGuo parents, have been characterized with regard to their acid-stabilities, octanol-water partition coefficients, and enzyme substrate properties for adenosine deaminase and purine nucleoside phosphorylase. F-ddGuo analogues are less potent but more stable than their non-fluorinated parent compounds." @default.
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- W1978268520 date "1994-03-01" @default.
- W1978268520 modified "2023-10-09" @default.
- W1978268520 title "Chemistry and Anti-HIV Activity of 2′-β-Fluoro-2′,3′-dideoxyguanosine" @default.
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- W1978268520 doi "https://doi.org/10.1080/15257779408013236" @default.
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