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- W1978271566 abstract "Freshly isolated rat hepatocytes, prepared by collagenase perfusion, exhibit a high rate of endogenous proteolysis which is unaffected by amino acids (added as a physiological mixture). However, ammonia, a natural product of amino acid catabolism, inhibits protein degradation as measured by the release from protein of either acid-soluble radioactivity or nitrogen (amino acids + urea). Incorporation of radioactive amino acids into protein is not affected. Thus, ammonia appears to inhibit endogenous hepatic protein degradation in a selective manner, providing a regulatory circuit of end-product inhibition." @default.
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- W1978271566 date "1975-09-01" @default.
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- W1978271566 title "Protein degradation in isolated rat hepatocytes is inhibited by ammonia" @default.
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- W1978271566 doi "https://doi.org/10.1016/s0006-291x(75)80292-0" @default.
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