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• W1978273241 abstract "We cultured lymph node lymphocytes (LNL) from lung cancer patients in the presence of recombinant interleukin 2 (rIL2). The ability of LNL to respond to rIL2 was not affected by the advance of cancer stage when tested for proliferation and for lymphokine-activated killer (LAK) activity. The LAK activity of LNL was comparable to that of the corresponding peripheral blood lymphocytes. The rIL2-induced proliferation of macrophage-depleted LNL was augmented by the reconstitution with autologous alveolar macrophages while the LAK activity was not affected. However, macrophage-reconstituted LNL expanded rapidly and reached higher cell densities and exhibited a significantly lower LAK activity than macrophage-depleted LNL. The diminished LAK activity in macrophage-reconstituted LNL were markedly augmented by the subculture at a low cell density. From these results, we conclude that LNL can be a good material for the postoperative LAK therapy and that macrophage is useful in culture of LAK cells." @default.
• W1978273241 created "2016-06-24" @default.
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• W1978273241 date "1989-02-01" @default.
• W1978273241 modified "2023-10-15" @default.
• W1978273241 title "Generation and expansion of lymphokine-activated killer cells from lymph node lymphocytes in human lung cancer" @default.
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• W1978273241 doi "https://doi.org/10.1016/0277-5379(89)90009-6" @default.
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