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• W1978276475 abstract "956 In order to identify factors leading to the development of alcoholic liver disease (ALD), and to plan therapy, we measured lifetime drinking and drug use histories, mood states, and motivation for change in 30 randomly chosen outpatients with ALD on a liver transplant waiting list and compared them with 30 presumed noncirrhotic alcoholic subjects (non-ALD) seeking alcoholism treatment. Subjects were matched for age, sex, race and socioeconomic status. The ALD subjects represented 6% of pts. referred for liver transplant evaluation between '96-'98 and 14% of ALD patients selected for transplantation. In both groups, alcohol was the primary addiction and no one had evidence of dependence on drugs other than nicotine within 30 days of evaluation. Mean age was 44 y/o with 12.5 - 14 years of education. 95% were white, 5% African American and 80% male. 63% were unmarried. Baseline differences were evaluated with t-tests for continuous measures and chi-squares for categorical measures. Results:Drinking Patterns: the interval from the last drink was significantly longer in the ALD cohort than the non-ALD group (mean 33.5 mos. vs. 1 mo.). Subjects in both groups began drinking at 17 y/o, SD=3-4. However, the ALD group had greater abstinence time (55 months SD=30 vs. 10 months SD=16, p=.000) within their drinking careers. ALD patients accumulated fewer years of total drinking (22 years v. 26 years, SD=6 vs., p=.005), and had more drinks per drinking day (8, SD=7 vs. 4, SD=3, p=.03), and more drinks per drinking year (3,000 drinks/year (SD=2,600) vs. 1,500 drinks/year (SD=1,100), p=.03). Drug Use: There was greater polydrug use among ALDs, especially IVDU. Significantly more ALD patients were infected with hepatitis C. Mood States: Non-ALDs had more depressive and anxiety symptoms than ALDs, but both groups were high. Motivation for Alcohol Treatment: Patients with ALD displayed significantly less insight into the need for alcoholism treatment and less commitment to seek treatment for their previous drinking related behaviors. Conclusions: Patients with ALD on the transplant waiting list drank more intensively with more frequent abstinence, had more drug use and less insight into their need for alcoholism treatment than non-ALDs. These data suggest that alcoholics with liver failure may be less amenable to traditional therapy for alcoholism. Future studies should address triggers to relapse and reasons for lack of motivation so that alcoholism therapies may be designed to be more acceptable among patients with ALD." @default.
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• W1978276475 date "1999-04-01" @default.
• W1978276475 modified "2023-10-16" @default.
• W1978276475 title "Drinking Behavior and Drug Use in Alcoholic Liver Transplant Candidates: A Comparison with Alcoholics in a Treatment Unit." @default.
• W1978276475 doi "https://doi.org/10.1097/00007890-199904150-00980" @default.
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