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- W1978279189 abstract "In today’s economically developed societies, IgEmediated allergic responses are regarded more as a hindrance than a help. Nevertheless, the ability to make such responses has probably played an important role in protecting our distant ancestors from the scourges of parasitic disease and, indeed, this function is probably still important in many underdeveloped countries.’ We may, therefore, regard the current relatively high prevalence of atopic allergy in the Western world as an unwanted vestige of a previously useful immune function. It seems likely that a genetic capacity toward hyperresponsiveness of the IgE system and concomitant high prevalence of allergy have exerted a weak selective disadvantage in white Europeans since Neolithic times, as parasitic disease became a decreasingly less severe problem. In modem man, the main selective pressure on specijc immune response has almost certainly been infectious disease-in particular, that caused by pathogens which strike before puberty with a high rate of mortality. Several authorP5 have argued convincingly that many of today’s common infectious diseases probably evolved only in the last 5,000 or 6,000" @default.
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- W1978279189 date "1980-05-01" @default.
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- W1978279189 title "Genetics of human immune response to allergens" @default.
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- W1978279189 doi "https://doi.org/10.1016/0091-6749(80)90208-0" @default.
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