FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978280736> ?p ?o ?g. }

• W1978280736 endingPage "63" @default.
• W1978280736 startingPage "56" @default.
• W1978280736 abstract "Objective: Eosinophils play an important role in some gastrointestinal inflammatory conditions. Stimulated eosinophils migrate across the vascular endothelial wall and into the intestinal epithelium where by-products such as proteases may contribute to intestinal epithelial damage. Little is known about the epithelial migration of the eosinophils in the gut. The lack of data is attributable in part to the scarcity of human eosinophils for studies. HL-60–differentiated eosinophils present a means to perform studies on eosinophil function and chemotaxis. HL-60 clone 15 can be induced to differentiate into cells closely resembling human eosinophils. The authors describe a novel model for studying eosinophil migration across the intestinal epithelium. Methods: Fluorescent-labeled HL-60 eosinophils were incubated for 150 minutes on the basolateral surface of confluent and inverted T-84 monolayers separated by fluoroblock insert membranes. Chemotactic gradients of n-formyl methionyl leucyl phenylalanine (fMLP), eotaxin, and platelet aggregating factor (PAF) were used in variable concentrations. Changes in transepithelial electrical resistance (TEER) were compared with baseline values. Results: Differentiated HL-60 eosinophils undergo migration in response to fMLP, PAF, and eotaxin. Migration is associated with a drop in TEER. Conclusion: In this model, HL-60–differentiated eosinophils migrate in response to stimulants chemotactic for human eosinophils. The transepithelial migration of eosinophils is associated with epithelial barrier dysfunction, which may contribute to the development of disease." @default.
• W1978280736 created "2016-06-24" @default.
• W1978280736 creator A5014642004 @default.
• W1978280736 creator A5042939281 @default.
• W1978280736 date "2004-07-01" @default.
• W1978280736 modified "2023-10-15" @default.
• W1978280736 title "A New Model for Studying Eosinophil Migration Across Cultured Intestinal Epithelial Monolayers" @default.
• W1978280736 cites W101185435 @default.
• W1978280736 cites W1499870879 @default.
• W1978280736 cites W1893528652 @default.
• W1978280736 cites W1965570330 @default.
• W1978280736 cites W1978875704 @default.
• W1978280736 cites W1986262580 @default.
• W1978280736 cites W1989242185 @default.
• W1978280736 cites W1991254311 @default.
• W1978280736 cites W1992298219 @default.
• W1978280736 cites W2004216239 @default.
• W1978280736 cites W2023986228 @default.
• W1978280736 cites W2032703344 @default.
• W1978280736 cites W2033043906 @default.
• W1978280736 cites W2043801077 @default.
• W1978280736 cites W2044955872 @default.
• W1978280736 cites W2051127535 @default.
• W1978280736 cites W2053916612 @default.
• W1978280736 cites W2060115591 @default.
• W1978280736 cites W2091913466 @default.
• W1978280736 cites W2124328573 @default.
• W1978280736 cites W2132018717 @default.
• W1978280736 cites W2133885613 @default.
• W1978280736 cites W2148520141 @default.
• W1978280736 cites W2154416360 @default.
• W1978280736 cites W2168048778 @default.
• W1978280736 cites W2254044315 @default.
• W1978280736 cites W276534841 @default.
• W1978280736 doi "https://doi.org/10.1097/00005176-200407000-00012" @default.
• W1978280736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15187782" @default.
• W1978280736 hasPublicationYear "2004" @default.
• W1978280736 type Work @default.
• W1978280736 sameAs 1978280736 @default.
• W1978280736 citedByCount "12" @default.
• W1978280736 countsByYear W19782807362012 @default.
• W1978280736 countsByYear W19782807362014 @default.
• W1978280736 crossrefType "journal-article" @default.
• W1978280736 hasAuthorship W1978280736A5014642004 @default.
• W1978280736 hasAuthorship W1978280736A5042939281 @default.
• W1978280736 hasBestOaLocation W19782807361 @default.
• W1978280736 hasConcept C13373296 @default.
• W1978280736 hasConcept C137738243 @default.
• W1978280736 hasConcept C142724271 @default.
• W1978280736 hasConcept C1491633281 @default.
• W1978280736 hasConcept C170493617 @default.
• W1978280736 hasConcept C203014093 @default.
• W1978280736 hasConcept C2776042228 @default.
• W1978280736 hasConcept C2776914184 @default.
• W1978280736 hasConcept C2777037409 @default.
• W1978280736 hasConcept C2777716647 @default.
• W1978280736 hasConcept C2778081958 @default.
• W1978280736 hasConcept C2781077229 @default.
• W1978280736 hasConcept C51911345 @default.
• W1978280736 hasConcept C529295009 @default.
• W1978280736 hasConcept C54166955 @default.
• W1978280736 hasConcept C55493867 @default.
• W1978280736 hasConcept C71924100 @default.
• W1978280736 hasConcept C86803240 @default.
• W1978280736 hasConcept C95444343 @default.
• W1978280736 hasConceptScore W1978280736C13373296 @default.
• W1978280736 hasConceptScore W1978280736C137738243 @default.
• W1978280736 hasConceptScore W1978280736C142724271 @default.
• W1978280736 hasConceptScore W1978280736C1491633281 @default.
• W1978280736 hasConceptScore W1978280736C170493617 @default.
• W1978280736 hasConceptScore W1978280736C203014093 @default.
• W1978280736 hasConceptScore W1978280736C2776042228 @default.
• W1978280736 hasConceptScore W1978280736C2776914184 @default.
• W1978280736 hasConceptScore W1978280736C2777037409 @default.
• W1978280736 hasConceptScore W1978280736C2777716647 @default.
• W1978280736 hasConceptScore W1978280736C2778081958 @default.
• W1978280736 hasConceptScore W1978280736C2781077229 @default.
• W1978280736 hasConceptScore W1978280736C51911345 @default.
• W1978280736 hasConceptScore W1978280736C529295009 @default.
• W1978280736 hasConceptScore W1978280736C54166955 @default.
• W1978280736 hasConceptScore W1978280736C55493867 @default.
• W1978280736 hasConceptScore W1978280736C71924100 @default.
• W1978280736 hasConceptScore W1978280736C86803240 @default.
• W1978280736 hasConceptScore W1978280736C95444343 @default.
• W1978280736 hasIssue "1" @default.
• W1978280736 hasLocation W19782807361 @default.
• W1978280736 hasLocation W19782807362 @default.
• W1978280736 hasLocation W19782807363 @default.
• W1978280736 hasOpenAccess W1978280736 @default.
• W1978280736 hasPrimaryLocation W19782807361 @default.
• W1978280736 hasRelatedWork W1216914929 @default.
• W1978280736 hasRelatedWork W2002233008 @default.
• W1978280736 hasRelatedWork W2013908818 @default.
• W1978280736 hasRelatedWork W2016049626 @default.
• W1978280736 hasRelatedWork W2035134747 @default.
• W1978280736 hasRelatedWork W2115575121 @default.
• W1978280736 hasRelatedWork W2159791496 @default.
• W1978280736 hasRelatedWork W2188467030 @default.

• next