FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978284967> ?p ?o ?g. }

• W1978284967 endingPage "14240" @default.
• W1978284967 startingPage "14232" @default.
• W1978284967 abstract "ABSTRACT CD4 + T-cell responses are crucial for effective antibody and CD8 + T-cell induction following virus infection. However, virus-specific CD4 + T cells can be preferential targets for human immunodeficiency virus (HIV) infection. HIV-specific CD4 + T-cell induction by vaccination may thus result in enhancement of virus replication following infection. In the present study, we show that vaccine-elicited CD4 + T cells expressing CD107a are relatively resistant to depletion in a macaque AIDS model. Comparison of virus-specific CD107a, macrophage inflammatory protein-1β, gamma interferon, tumor necrosis factor alpha, and interleukin-2 responses in CD4 + T cells of vaccinated macaques prechallenge and 1 week postchallenge showed a significant reduction in the CD107a − but not the CD107a + subset after virus exposure. Those vaccinees that failed to control viremia showed a more marked reduction and exhibited significantly higher viral loads at week 1 than unvaccinated animals. Our results indicate that vaccine-induced CD107a − CD4 + T cells are depleted following virus infection, suggesting a rationale for avoiding virus-specific CD107a − CD4 + T-cell induction in HIV vaccine design. IMPORTANCE Induction of effective antibody and/or CD8 + T-cell responses is a principal vaccine strategy against human immunodeficiency virus (HIV) infection. CD4 + T-cell responses are crucial for effective antibody and CD8 + T-cell induction. However, virus-specific CD4 + T cells can be preferential targets for HIV infection. Here, we show that vaccine-induced virus-specific CD107a − CD4 + T cells are largely depleted following infection in a macaque AIDS model. While CD4 + T-cell responses are important in viral control, our results indicate that virus-specific CD107a − CD4 + T-cell induction by vaccination may not lead to efficient CD4 + T-cell responses following infection but rather be detrimental and accelerate viral replication in the acute phase. This suggests that HIV vaccine design should avoid virus-specific CD107a − CD4 + T-cell induction. Conversely, this study found that vaccine-induced CD107a + CD4 + T cells are relatively resistant to depletion following virus challenge, implying that induction of these cells may be an alternative approach toward HIV control." @default.
• W1978284967 created "2016-06-24" @default.
• W1978284967 creator A5000432683 @default.
• W1978284967 creator A5028559595 @default.
• W1978284967 creator A5042245279 @default.
• W1978284967 creator A5055768106 @default.
• W1978284967 creator A5066805703 @default.
• W1978284967 creator A5074466220 @default.
• W1978284967 creator A5086378954 @default.
• W1978284967 creator A5089081003 @default.
• W1978284967 date "2014-12-15" @default.
• W1978284967 modified "2023-10-17" @default.
• W1978284967 title "Vaccine-Induced CD107a⁺CD4⁺T Cells Are Resistant to Depletion following AIDS Virus Infection" @default.
• W1978284967 cites W1493822493 @default.
• W1978284967 cites W1528520360 @default.
• W1978284967 cites W1655510925 @default.
• W1978284967 cites W1656874207 @default.
• W1978284967 cites W1973619416 @default.
• W1978284967 cites W1974433492 @default.
• W1978284967 cites W1984999783 @default.
• W1978284967 cites W1990388100 @default.
• W1978284967 cites W1994744932 @default.
• W1978284967 cites W1999396723 @default.
• W1978284967 cites W2003313366 @default.
• W1978284967 cites W2008667095 @default.
• W1978284967 cites W2011340131 @default.
• W1978284967 cites W2011541285 @default.
• W1978284967 cites W2024524568 @default.
• W1978284967 cites W2025481552 @default.
• W1978284967 cites W2027265343 @default.
• W1978284967 cites W2029135056 @default.
• W1978284967 cites W2037343680 @default.
• W1978284967 cites W2045551237 @default.
• W1978284967 cites W2047305605 @default.
• W1978284967 cites W2054395379 @default.
• W1978284967 cites W2057961805 @default.
• W1978284967 cites W2061357389 @default.
• W1978284967 cites W2073449362 @default.
• W1978284967 cites W2075345074 @default.
• W1978284967 cites W2076225720 @default.
• W1978284967 cites W2076534074 @default.
• W1978284967 cites W2076723714 @default.
• W1978284967 cites W2088147238 @default.
• W1978284967 cites W2093264896 @default.
• W1978284967 cites W2099182602 @default.
• W1978284967 cites W2100713536 @default.
• W1978284967 cites W2103182811 @default.
• W1978284967 cites W2107201675 @default.
• W1978284967 cites W2113708505 @default.
• W1978284967 cites W2115180633 @default.
• W1978284967 cites W2116097076 @default.
• W1978284967 cites W2124969212 @default.
• W1978284967 cites W2126579489 @default.
• W1978284967 cites W2126851513 @default.
• W1978284967 cites W2128161673 @default.
• W1978284967 cites W2134120586 @default.
• W1978284967 cites W2139257243 @default.
• W1978284967 cites W2142405752 @default.
• W1978284967 cites W2144780961 @default.
• W1978284967 cites W2144882745 @default.
• W1978284967 cites W2146780788 @default.
• W1978284967 cites W2148873007 @default.
• W1978284967 cites W2151130810 @default.
• W1978284967 cites W2154496648 @default.
• W1978284967 cites W2155025120 @default.
• W1978284967 cites W2158836440 @default.
• W1978284967 cites W2162828632 @default.
• W1978284967 doi "https://doi.org/10.1128/jvi.02032-14" @default.
• W1978284967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4249136" @default.
• W1978284967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25275131" @default.
• W1978284967 hasPublicationYear "2014" @default.
• W1978284967 type Work @default.
• W1978284967 sameAs 1978284967 @default.
• W1978284967 citedByCount "22" @default.
• W1978284967 countsByYear W19782849672015 @default.
• W1978284967 countsByYear W19782849672016 @default.
• W1978284967 countsByYear W19782849672017 @default.
• W1978284967 countsByYear W19782849672018 @default.
• W1978284967 countsByYear W19782849672019 @default.
• W1978284967 countsByYear W19782849672020 @default.
• W1978284967 countsByYear W19782849672021 @default.
• W1978284967 countsByYear W19782849672022 @default.
• W1978284967 countsByYear W19782849672023 @default.
• W1978284967 crossrefType "journal-article" @default.
• W1978284967 hasAuthorship W1978284967A5000432683 @default.
• W1978284967 hasAuthorship W1978284967A5028559595 @default.
• W1978284967 hasAuthorship W1978284967A5042245279 @default.
• W1978284967 hasAuthorship W1978284967A5055768106 @default.
• W1978284967 hasAuthorship W1978284967A5066805703 @default.
• W1978284967 hasAuthorship W1978284967A5074466220 @default.
• W1978284967 hasAuthorship W1978284967A5086378954 @default.
• W1978284967 hasAuthorship W1978284967A5089081003 @default.
• W1978284967 hasBestOaLocation W19782849671 @default.
• W1978284967 hasConcept C140704245 @default.
• W1978284967 hasConcept C151730666 @default.
• W1978284967 hasConcept C159047783 @default.
• W1978284967 hasConcept C159654299 @default.
• W1978284967 hasConcept C167672396 @default.

• next