Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978286224> ?p ?o ?g. }
- W1978286224 endingPage "442" @default.
- W1978286224 startingPage "433" @default.
- W1978286224 abstract "In yeast, the type 1 protein phosphatase (PP1) catalytic subunit Glc7 is involved in the regulation of multiple cellular processes and thought to achieve specificity through association with different regulatory subunits. Here, we report that the Glc7 regulator Shp1 plays important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans. SHP1 deletion caused the formation of rod-shaped yeast cells with slow growth. Flow cytometry analysis revealed that shp1Δ cells showed a prolonged G(2)/M phase, which was rescued by deleting the spindle-checkpoint gene MAD2. Furthermore, shp1Δ cells were hypersensitive to heat and genotoxic stresses. Interestingly, depletion of Glc7 caused defects similar to the shp1Δ mutant such as arrest at G(2)/M transition; and the GLC7/glc7Δ heterozygous mutant exhibited increased sensitivity to genotoxic stresses, consistent with the recent finding that Saccharomyces cerevisiae Glc7 has a role in DNA damage response. We also show that Shp1 is required for the nuclear accumulation of Glc7, suggesting that Shp1 executes its cellular function partly by regulating Glc7 localization." @default.
- W1978286224 created "2016-06-24" @default.
- W1978286224 creator A5033632697 @default.
- W1978286224 creator A5035776554 @default.
- W1978286224 creator A5052636019 @default.
- W1978286224 creator A5057164629 @default.
- W1978286224 creator A5078988597 @default.
- W1978286224 creator A5087404367 @default.
- W1978286224 date "2012-06-01" @default.
- W1978286224 modified "2023-09-26" @default.
- W1978286224 title "Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans" @default.
- W1978286224 cites W133394743 @default.
- W1978286224 cites W1837394676 @default.
- W1978286224 cites W1937476509 @default.
- W1978286224 cites W1962398190 @default.
- W1978286224 cites W1967864456 @default.
- W1978286224 cites W1987929315 @default.
- W1978286224 cites W1993122323 @default.
- W1978286224 cites W1994963031 @default.
- W1978286224 cites W1997437177 @default.
- W1978286224 cites W1999340863 @default.
- W1978286224 cites W2002379595 @default.
- W1978286224 cites W2004008931 @default.
- W1978286224 cites W2008169967 @default.
- W1978286224 cites W2011758386 @default.
- W1978286224 cites W2027306848 @default.
- W1978286224 cites W2029326415 @default.
- W1978286224 cites W2040362471 @default.
- W1978286224 cites W2041978081 @default.
- W1978286224 cites W2047254556 @default.
- W1978286224 cites W2049219353 @default.
- W1978286224 cites W2054650920 @default.
- W1978286224 cites W2055743739 @default.
- W1978286224 cites W2067823655 @default.
- W1978286224 cites W2071466638 @default.
- W1978286224 cites W2081148187 @default.
- W1978286224 cites W2099624816 @default.
- W1978286224 cites W2113120391 @default.
- W1978286224 cites W2131266367 @default.
- W1978286224 cites W2133503471 @default.
- W1978286224 cites W2133516385 @default.
- W1978286224 cites W2133643647 @default.
- W1978286224 cites W2137717902 @default.
- W1978286224 cites W2140935709 @default.
- W1978286224 cites W2142140971 @default.
- W1978286224 cites W2148855999 @default.
- W1978286224 cites W2152304690 @default.
- W1978286224 cites W2159607643 @default.
- W1978286224 cites W2162555780 @default.
- W1978286224 cites W2164017201 @default.
- W1978286224 cites W2166178588 @default.
- W1978286224 cites W2167221234 @default.
- W1978286224 cites W2170308357 @default.
- W1978286224 cites W2171202879 @default.
- W1978286224 cites W2222283485 @default.
- W1978286224 cites W4239235909 @default.
- W1978286224 doi "https://doi.org/10.1016/j.fgb.2012.04.004" @default.
- W1978286224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22542681" @default.
- W1978286224 hasPublicationYear "2012" @default.
- W1978286224 type Work @default.
- W1978286224 sameAs 1978286224 @default.
- W1978286224 citedByCount "10" @default.
- W1978286224 countsByYear W19782862242014 @default.
- W1978286224 countsByYear W19782862242015 @default.
- W1978286224 countsByYear W19782862242016 @default.
- W1978286224 countsByYear W19782862242018 @default.
- W1978286224 countsByYear W19782862242021 @default.
- W1978286224 countsByYear W19782862242023 @default.
- W1978286224 crossrefType "journal-article" @default.
- W1978286224 hasAuthorship W1978286224A5033632697 @default.
- W1978286224 hasAuthorship W1978286224A5035776554 @default.
- W1978286224 hasAuthorship W1978286224A5052636019 @default.
- W1978286224 hasAuthorship W1978286224A5057164629 @default.
- W1978286224 hasAuthorship W1978286224A5078988597 @default.
- W1978286224 hasAuthorship W1978286224A5087404367 @default.
- W1978286224 hasConcept C104292427 @default.
- W1978286224 hasConcept C104317684 @default.
- W1978286224 hasConcept C11960822 @default.
- W1978286224 hasConcept C120504264 @default.
- W1978286224 hasConcept C143065580 @default.
- W1978286224 hasConcept C143425029 @default.
- W1978286224 hasConcept C1491633281 @default.
- W1978286224 hasConcept C178666793 @default.
- W1978286224 hasConcept C2777576037 @default.
- W1978286224 hasConcept C2779222958 @default.
- W1978286224 hasConcept C2779408958 @default.
- W1978286224 hasConcept C2780917455 @default.
- W1978286224 hasConcept C29537977 @default.
- W1978286224 hasConcept C40692019 @default.
- W1978286224 hasConcept C54355233 @default.
- W1978286224 hasConcept C552990157 @default.
- W1978286224 hasConcept C55493867 @default.
- W1978286224 hasConcept C86803240 @default.
- W1978286224 hasConcept C95444343 @default.
- W1978286224 hasConceptScore W1978286224C104292427 @default.
- W1978286224 hasConceptScore W1978286224C104317684 @default.
- W1978286224 hasConceptScore W1978286224C11960822 @default.
- W1978286224 hasConceptScore W1978286224C120504264 @default.