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• W1978287377 startingPage "13" @default.
• W1978287377 abstract "Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin. Here, we report an increase in vimentin gene transcription induced by the cytokine interferon-gamma (IFN-gamma). Northern blot analysis and reporter gene assays reveal that IFN-gamma induces vimentin gene transcription in HeLa cells. However, no increase in vimentin mRNA synthesis was observed de novo in MCF-7 cells, which do not already express vimentin. Band shift analysis shows that the Stat1 alpha protein mediates vimentin induction by IFN-gamma. A human mutant fibroblast cell line (U3A), which lacks Stat1 alpha but expresses vimentin mRNA, yields no increase in vimentin mRNA levels on the addition of IFN-gamma. These results suggest that the induction of vimentin gene expression might be an important part of a complex cellular response to IFN-gamma." @default.
• W1978287377 created "2016-06-24" @default.
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• W1978287377 date "2000-01-01" @default.
• W1978287377 modified "2023-09-29" @default.
• W1978287377 title "A Stat 1alpha Factor Regulates the Expression of the Human Vimentin Gene by IFN-gamma" @default.
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• W1978287377 doi "https://doi.org/10.1089/107999000312694" @default.
• W1978287377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10670648" @default.
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