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- W1978291235 abstract "It is now widely recognized that substrate viscoelasticity may have a profound impact on cellular fate and function. However, the underlying mechanisms of cellular mechano-sensing remain a topic of open debate. Traditionally, cellular mechano-regulation was accomplished using polymeric substrates of adjustable viscoelasticity with immobilized cell linkers. Here, we present an alternative strategy of cellular mechano-regulation, in which the viscous drag of cell-substrate linkers is altered by the number of lipid bilayers in a polymer-tethered multi-bilayer stack. 3T3 fibroblast experiments on laminin-functionalized bilayer substrates show that the number of bilayers has a significant impact on cell morphology, migration, and cytoskeletal organization. Furthermore, this biomembrane-mimicking substrate is integrated into a force traction microscopy assay, which confirms that the presence of the fluid multi-bilayer system leads to a notable reduction in cellular traction forces. In addition to fibroblast experiments on laminin-functionalized substrates, we have also designed a cadherin-functionalized multi-bilayer system, which better replicates the conditions of a cell-cell linkage. These substrates were employed to explore the spreading and migration behavior of myoblasts. Our experiments indicate that the described biomembrane-mimicking substrates are particularly well-suited to study plated cells under weak force traction conditions." @default.
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- W1978291235 date "2012-01-01" @default.
- W1978291235 modified "2023-09-26" @default.
- W1978291235 title "Cellular Mechano-Stimulation by Adjusting the Viscous Drag of Cell-Substrate Linkers in Biomembrane-Mimicking Cell Substrates" @default.
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- W1978291235 doi "https://doi.org/10.1016/j.bpj.2011.11.3075" @default.
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