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- W1978291239 abstract "Subnormal ventilatory response to hypercapnia is accepted as part of the obesity-hypoventilation syndrome in adults, but ventilatory control has not been studied in children with the obesity-hypoventilation syndrome. We studied ventilatory response to hypercapnia in the families of 2 obese 13-year-old girls with the Prader-Willi Syndrome, one of whom had recovered from the obesity hypoventilation syndrome, and one of whom had never hypoventilated. Siblings and parents were not obese. The response to hypercapnia, measured as the slope (S) of ventilation (L/min) vs. alveolar carbon dioxide tension (mmHg) during rebreathing, was decreased in the patient with the obesity-hypoventilation syndrome (S=1.0) and in 3 family members (mean S=1.1, range .7-1.4). The other Prader-Willi patient (S=3.6) and her family (mean S=2.2, range 1.6-3.6) had considerably greater responses. Young adult controls (mean S=3.3, range 2.8-4.2) fell within published normal ranges (S=1.5 - 5.0). Respiratory failure in the child with the obesity-hypoventilation syndrome is probably related to two independent factors: obesity and a familial diminished response to hypercapnia. The familial factor may explain why only a small percentage of obese patients develop the obesity-hypoventilation syndrome." @default.
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- W1978291239 date "1977-04-01" @default.
- W1978291239 modified "2023-09-23" @default.
- W1978291239 title "ASSOCIATION OF CHILDHOOD OBESITY-HYPOVENTILATION SYNDROME AND FAMILIAL DECREASED VENTILATORY RESPONSE TO HYPERCAPNIA" @default.
- W1978291239 doi "https://doi.org/10.1203/00006450-197704000-01240" @default.
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