Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978293455> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1978293455 endingPage "103" @default.
- W1978293455 startingPage "99" @default.
- W1978293455 abstract "Objective: To localize estrogen receptor-α (ER-α) and estrogen receptor-β (ER-β) within the growth plate and adjacent bony tissue of children in the prepubertal and pubertal age period. Methods: Tissue was taken during orthopedic surgery (epiphysiodesis) for correction of congenital or traumatic leg length difference in 2 prepubertal females and 2 adolescent males. Immunohistochemistry was performed on paraffin-embedded or cryostat sections by using commercially available rabbit polyclonal antibodies for ER-α and ER-β. Results: Both ER-α and ER-β were detected within the growth plate in all sections investigated. Immunostaining was restricted to hypertrophic chondrocytes. In the bony tissue adjacent to the growth plate, osteoblasts stained positive for both ER-α and ER-β, whereas osteocytes and osteoclasts were negative. Staining with ER-α was mainly nuclear but some cells also showed cytoplasmic signals, while ER-β staining was predominantly cytoplasmic, only few nuclei stained positive. There was no difference in the local distribution of both ERs between tissue from prepubertal and pubertal patients. Conclusion: Our findings indicate that the hypertrophic chondrocyte is the main target cell for estrogen action within the growth plate. The presence of ER in prepubertal children suggests that estrogens play a role in skeletal maturation under physiological conditions also in this age-group." @default.
- W1978293455 created "2016-06-24" @default.
- W1978293455 creator A5030159697 @default.
- W1978293455 creator A5054717203 @default.
- W1978293455 creator A5061262968 @default.
- W1978293455 creator A5086791556 @default.
- W1978293455 date "2002-01-01" @default.
- W1978293455 modified "2023-09-27" @default.
- W1978293455 title "Estrogen Receptor-Alpha and Estrogen Receptor-Beta Are Present in the Human Growth Plate in Childhood and Adolescence, in Identical Distribution" @default.
- W1978293455 cites W1970792195 @default.
- W1978293455 cites W1973350140 @default.
- W1978293455 cites W1979903836 @default.
- W1978293455 cites W1981306061 @default.
- W1978293455 cites W1984832581 @default.
- W1978293455 cites W1988611170 @default.
- W1978293455 cites W2008071275 @default.
- W1978293455 cites W2012076119 @default.
- W1978293455 cites W2025597791 @default.
- W1978293455 cites W2030139023 @default.
- W1978293455 cites W2056493785 @default.
- W1978293455 cites W2059913924 @default.
- W1978293455 cites W2062729355 @default.
- W1978293455 cites W2073353512 @default.
- W1978293455 cites W2116679015 @default.
- W1978293455 cites W2136672074 @default.
- W1978293455 cites W2140592897 @default.
- W1978293455 cites W2146408916 @default.
- W1978293455 cites W2158140522 @default.
- W1978293455 cites W2172256092 @default.
- W1978293455 cites W2321613759 @default.
- W1978293455 cites W2324075496 @default.
- W1978293455 doi "https://doi.org/10.1159/000064661" @default.
- W1978293455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12207170" @default.
- W1978293455 hasPublicationYear "2002" @default.
- W1978293455 type Work @default.
- W1978293455 sameAs 1978293455 @default.
- W1978293455 citedByCount "16" @default.
- W1978293455 countsByYear W19782934552018 @default.
- W1978293455 countsByYear W19782934552019 @default.
- W1978293455 countsByYear W19782934552021 @default.
- W1978293455 crossrefType "journal-article" @default.
- W1978293455 hasAuthorship W1978293455A5030159697 @default.
- W1978293455 hasAuthorship W1978293455A5054717203 @default.
- W1978293455 hasAuthorship W1978293455A5061262968 @default.
- W1978293455 hasAuthorship W1978293455A5086791556 @default.
- W1978293455 hasConcept C121608353 @default.
- W1978293455 hasConcept C126322002 @default.
- W1978293455 hasConcept C134018914 @default.
- W1978293455 hasConcept C172313692 @default.
- W1978293455 hasConcept C204232928 @default.
- W1978293455 hasConcept C2777164284 @default.
- W1978293455 hasConcept C4224716 @default.
- W1978293455 hasConcept C530470458 @default.
- W1978293455 hasConcept C71924100 @default.
- W1978293455 hasConcept C84606932 @default.
- W1978293455 hasConcept C86803240 @default.
- W1978293455 hasConcept C96307122 @default.
- W1978293455 hasConceptScore W1978293455C121608353 @default.
- W1978293455 hasConceptScore W1978293455C126322002 @default.
- W1978293455 hasConceptScore W1978293455C134018914 @default.
- W1978293455 hasConceptScore W1978293455C172313692 @default.
- W1978293455 hasConceptScore W1978293455C204232928 @default.
- W1978293455 hasConceptScore W1978293455C2777164284 @default.
- W1978293455 hasConceptScore W1978293455C4224716 @default.
- W1978293455 hasConceptScore W1978293455C530470458 @default.
- W1978293455 hasConceptScore W1978293455C71924100 @default.
- W1978293455 hasConceptScore W1978293455C84606932 @default.
- W1978293455 hasConceptScore W1978293455C86803240 @default.
- W1978293455 hasConceptScore W1978293455C96307122 @default.
- W1978293455 hasIssue "2" @default.
- W1978293455 hasLocation W19782934551 @default.
- W1978293455 hasLocation W19782934552 @default.
- W1978293455 hasOpenAccess W1978293455 @default.
- W1978293455 hasPrimaryLocation W19782934551 @default.
- W1978293455 hasRelatedWork W1965752471 @default.
- W1978293455 hasRelatedWork W1995389827 @default.
- W1978293455 hasRelatedWork W2009485082 @default.
- W1978293455 hasRelatedWork W2012888249 @default.
- W1978293455 hasRelatedWork W2037717279 @default.
- W1978293455 hasRelatedWork W2046600857 @default.
- W1978293455 hasRelatedWork W2120758873 @default.
- W1978293455 hasRelatedWork W2141285552 @default.
- W1978293455 hasRelatedWork W2364968244 @default.
- W1978293455 hasRelatedWork W2914741089 @default.
- W1978293455 hasVolume "58" @default.
- W1978293455 isParatext "false" @default.
- W1978293455 isRetracted "false" @default.
- W1978293455 magId "1978293455" @default.
- W1978293455 workType "article" @default.