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- W1978295148 abstract "We performed [123I]FP-CIT/SPECT in 20 drug-naive Parkinson's disease (PD) patients, 10 with unilateral akinesia/rigidity at onset (arPD) and 10 with additional tremor-at-rest (tPD), to evaluate whether resting tremor at onset is associated with differences in striatal dopamine transporter binding. Patients of the two cohorts were matched for age, disease duration (<3 years) and severity of non-tremor motor symptoms; 31 healthy participants served as controls. Mean striatal dopamine transporter binding reduction in PD patients vs. controls was 42% for arPD and 50% for tPD; mean ipsilateral striatum and caudate nucleus uptake values were lower by 12 and 24%, respectively, in tPD than arPD. We conclude that widespread degeneration of the nigrostriatal dopaminergic pathway might be necessary for the development of parkinsonian tremor-at-rest." @default.
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- W1978295148 date "2007-09-17" @default.
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- W1978295148 title "[123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset" @default.
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- W1978295148 doi "https://doi.org/10.1097/wnr.0b013e3282ef69f9" @default.
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