FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978297844> ?p ?o ?g. }

• W1978297844 endingPage "864" @default.
• W1978297844 startingPage "853" @default.
• W1978297844 abstract "Abstract The different psychomotor‐stimulant effects of cocaine, GBR12909, and benztropine may partially stem from their different molecular actions on the dopamine transporter (DAT). To explore this possibility, we examined binding of these inhibitors to mutated DATs with altered Na + dependence of DAT activities and with enhanced binding of a cocaine analog, [ 3 H]2β‐carbomethoxy‐3β‐(4‐fluorophenyl)tropane (CFT). In [ 3 H]CFT competition assays with intact cells, the mutation‐induced change in the ability of Na + to enhance the apparent affinity of CFT, cocaine, GBR12909, and benztropine was inhibitor‐independent. Thus, for the four inhibitors, the curve of [Na + ] versus apparent ligand affinity was steeper at W84L compared with wild type, shallower at D313N, and flat at W84LD313N. At each mutant, the apparent affinity of CFT and cocaine was enhanced regardless of whether Na + was present. However, the apparent affinity of GBR12909 and benztropine for W84L was reduced in the absence of Na + but near normal in the presence of 130 m m Na + , and that for D313N and W84LD313N was barely changed. At the single mutants, the alterations in Na + dependence and apparent affinity of the four inhibitors were comparable between [ 3 H]CFT competition assays and [ 3 H]dopamine uptake inhibition assays. These results demonstrate that DAT inhibitors producing different behavioral profiles can respond in an opposite way when residues of the DAT protein are mutated. For GBR12909 and benztropine, their cocaine‐like changes in Na + dependence suggest that they prefer a DAT state similar to that for cocaine. However, their cocaine‐unlike changes in apparent affinity argue that they, likely via their diphenylmethoxy moiety, share DAT binding epitopes that are different from those for cocaine." @default.
• W1978297844 created "2016-06-24" @default.
• W1978297844 creator A5020951431 @default.
• W1978297844 creator A5037793321 @default.
• W1978297844 creator A5058670474 @default.
• W1978297844 date "2004-04-13" @default.
• W1978297844 modified "2023-09-29" @default.
• W1978297844 title "Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine" @default.
• W1978297844 cites W1506380287 @default.
• W1978297844 cites W1518262527 @default.
• W1978297844 cites W1606219989 @default.
• W1978297844 cites W1877347825 @default.
• W1978297844 cites W1965835906 @default.
• W1978297844 cites W1966183574 @default.
• W1978297844 cites W1975591144 @default.
• W1978297844 cites W1975912352 @default.
• W1978297844 cites W1985442468 @default.
• W1978297844 cites W1988962265 @default.
• W1978297844 cites W1989890649 @default.
• W1978297844 cites W1991442236 @default.
• W1978297844 cites W2001671995 @default.
• W1978297844 cites W2003586175 @default.
• W1978297844 cites W2004776357 @default.
• W1978297844 cites W2010416288 @default.
• W1978297844 cites W2014793858 @default.
• W1978297844 cites W2024474477 @default.
• W1978297844 cites W2035252936 @default.
• W1978297844 cites W2044024401 @default.
• W1978297844 cites W2047143254 @default.
• W1978297844 cites W2049055505 @default.
• W1978297844 cites W2052590859 @default.
• W1978297844 cites W2056497347 @default.
• W1978297844 cites W2063752616 @default.
• W1978297844 cites W2064225780 @default.
• W1978297844 cites W2071280486 @default.
• W1978297844 cites W2081694946 @default.
• W1978297844 cites W2082450996 @default.
• W1978297844 cites W2103560063 @default.
• W1978297844 cites W2104146862 @default.
• W1978297844 cites W2119117083 @default.
• W1978297844 cites W2130676801 @default.
• W1978297844 cites W2133447074 @default.
• W1978297844 cites W2145533695 @default.
• W1978297844 cites W2166601414 @default.
• W1978297844 cites W2166640893 @default.
• W1978297844 cites W2208580072 @default.
• W1978297844 cites W4251093135 @default.
• W1978297844 doi "https://doi.org/10.1111/j.1471-4159.2004.02386.x" @default.
• W1978297844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15140185" @default.
• W1978297844 hasPublicationYear "2004" @default.
• W1978297844 type Work @default.
• W1978297844 sameAs 1978297844 @default.
• W1978297844 citedByCount "71" @default.
• W1978297844 countsByYear W19782978442012 @default.
• W1978297844 countsByYear W19782978442013 @default.
• W1978297844 countsByYear W19782978442014 @default.
• W1978297844 countsByYear W19782978442015 @default.
• W1978297844 countsByYear W19782978442016 @default.
• W1978297844 countsByYear W19782978442017 @default.
• W1978297844 countsByYear W19782978442018 @default.
• W1978297844 countsByYear W19782978442019 @default.
• W1978297844 countsByYear W19782978442020 @default.
• W1978297844 countsByYear W19782978442023 @default.
• W1978297844 crossrefType "journal-article" @default.
• W1978297844 hasAuthorship W1978297844A5020951431 @default.
• W1978297844 hasAuthorship W1978297844A5037793321 @default.
• W1978297844 hasAuthorship W1978297844A5058670474 @default.
• W1978297844 hasBestOaLocation W19782978441 @default.
• W1978297844 hasConcept C104317684 @default.
• W1978297844 hasConcept C116569031 @default.
• W1978297844 hasConcept C134018914 @default.
• W1978297844 hasConcept C149011108 @default.
• W1978297844 hasConcept C170493617 @default.
• W1978297844 hasConcept C185592680 @default.
• W1978297844 hasConcept C2776755682 @default.
• W1978297844 hasConcept C2776995303 @default.
• W1978297844 hasConcept C2909816965 @default.
• W1978297844 hasConcept C2910393698 @default.
• W1978297844 hasConcept C513476851 @default.
• W1978297844 hasConcept C55493867 @default.
• W1978297844 hasConcept C71240020 @default.
• W1978297844 hasConcept C86803240 @default.
• W1978297844 hasConcept C98274493 @default.
• W1978297844 hasConceptScore W1978297844C104317684 @default.
• W1978297844 hasConceptScore W1978297844C116569031 @default.
• W1978297844 hasConceptScore W1978297844C134018914 @default.
• W1978297844 hasConceptScore W1978297844C149011108 @default.
• W1978297844 hasConceptScore W1978297844C170493617 @default.
• W1978297844 hasConceptScore W1978297844C185592680 @default.
• W1978297844 hasConceptScore W1978297844C2776755682 @default.
• W1978297844 hasConceptScore W1978297844C2776995303 @default.
• W1978297844 hasConceptScore W1978297844C2909816965 @default.
• W1978297844 hasConceptScore W1978297844C2910393698 @default.
• W1978297844 hasConceptScore W1978297844C513476851 @default.
• W1978297844 hasConceptScore W1978297844C55493867 @default.
• W1978297844 hasConceptScore W1978297844C71240020 @default.
• W1978297844 hasConceptScore W1978297844C86803240 @default.
• W1978297844 hasConceptScore W1978297844C98274493 @default.

• next