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- W1978302022 abstract "Abstract The effect of loperamide on cholinergic neurotransmission in canine bronchial smooth muscle was studied under isometric conditions in-vitro. Addition of loperamide decreased contractile responses to electrical field stimulation in a dose-dependent fashion, the maximal decrease from the control response and the IC50 value being 65·4 ± 5·9% and 1·5 μm, respectively. In contrast, loperamide was without effect on the responses to exogenously administered acetylcholine. The inhibitory effect of loperamide was not altered by pre-incubation of tissues with propranol, 6-hydroxydopamine, bicuculline, or naloxone. These results suggest that loperamide attenuates the neurally mediated airway contraction probably by inhibiting acetylcholine release from cholinergic nerve terminals through a non-opioid-dependent mechanism." @default.
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- W1978302022 date "1992-04-01" @default.
- W1978302022 modified "2023-09-27" @default.
- W1978302022 title "Non-opioid-dependent Inhibitory Action of Loperamide on Cholinergic Neurotransmission in Canine Isolated Bronchial Smooth Muscle" @default.
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- W1978302022 doi "https://doi.org/10.1111/j.2042-7158.1992.tb03615.x" @default.
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