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• W1978302597 endingPage "502" @default.
• W1978302597 startingPage "491" @default.
• W1978302597 abstract "The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess of BAFF leads to the development of autoimmune disorders in animal models, and high levels of BAFF have been detected in the serum of patients with various autoimmune conditions. In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance. We also outline the mechanisms of BAFF signalling, the impact of ligand oligomerization on receptor activation and the progress of BAFF-depleting agents in the clinical setting." @default.
• W1978302597 created "2016-06-24" @default.
• W1978302597 creator A5012762666 @default.
• W1978302597 creator A5045281805 @default.
• W1978302597 date "2009-07-01" @default.
• W1978302597 modified "2023-10-12" @default.
• W1978302597 title "Cracking the BAFF code" @default.
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