Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978309095> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1978309095 endingPage "22" @default.
- W1978309095 startingPage "9" @default.
- W1978309095 abstract "An enzyme-linked immunosorbent assay was developed to detect serum antibody binding to liver membrane antigen derived from human hepatoma cell line SK-Hep-1. When we tested sera from 214 patients with this assay, IgM antibodies were detected in 100% of patients with acute type A, but not with type B or non-A, non-B hepatitis. IgM antibodies were also found in highest frequency (76%) and titer in patients with autoimmune chronic active hepatitis (CAH) among chronic liver disease groups. IgG antibodies occurred in over 50% of patients with acute type A hepatitis, type B chronic active liver disease (CALD), and autoimmune CAH. IgA antibodies were present in 43% of the patients with alcoholic liver disease, but were also seen in other patient groups. When freshly isolated rat hepatocytes were used as target cells, prevalences and titers similar to those obtained with SK-Hep-1 were found. The levels of serum membrane binding antibody were significantly reduced by the addition of human liver-specific membrane lipoprotein in all patient groups. In particular, IgM antibodies became negative in over 50% of patients with CALD (both type B and non-A, non-B) and autoimmune CAH, whereas in acute hepatitis over 50% lost their positivity for IgG antibody. These results indicate that circulating liver membrane binding autoantibodies are heterogeneous, occurring in hepatitis virus-induced acute and chronic liver disease as well as in autoimmune CAH." @default.
- W1978309095 created "2016-06-24" @default.
- W1978309095 creator A5021505548 @default.
- W1978309095 creator A5049541613 @default.
- W1978309095 creator A5068240015 @default.
- W1978309095 creator A5068498952 @default.
- W1978309095 date "1987-04-01" @default.
- W1978309095 modified "2023-09-25" @default.
- W1978309095 title "Autoantibodies against liver cell membrane antigens detected by enzyme-linked immunosorbent assay in acute and chronic liver disease" @default.
- W1978309095 cites W1490154674 @default.
- W1978309095 cites W1505656930 @default.
- W1978309095 cites W1607137338 @default.
- W1978309095 cites W1675392163 @default.
- W1978309095 cites W191584157 @default.
- W1978309095 cites W1968888088 @default.
- W1978309095 cites W2033554515 @default.
- W1978309095 cites W204273021 @default.
- W1978309095 cites W2059543592 @default.
- W1978309095 cites W2079546852 @default.
- W1978309095 cites W2117970905 @default.
- W1978309095 cites W2164620775 @default.
- W1978309095 cites W2326990808 @default.
- W1978309095 cites W2329053149 @default.
- W1978309095 cites W2401317396 @default.
- W1978309095 cites W2414187800 @default.
- W1978309095 cites W2414539979 @default.
- W1978309095 cites W2416840656 @default.
- W1978309095 cites W64637692 @default.
- W1978309095 cites W176638218 @default.
- W1978309095 doi "https://doi.org/10.1016/0090-1229(87)90153-x" @default.
- W1978309095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3829457" @default.
- W1978309095 hasPublicationYear "1987" @default.
- W1978309095 type Work @default.
- W1978309095 sameAs 1978309095 @default.
- W1978309095 citedByCount "5" @default.
- W1978309095 crossrefType "journal-article" @default.
- W1978309095 hasAuthorship W1978309095A5021505548 @default.
- W1978309095 hasAuthorship W1978309095A5049541613 @default.
- W1978309095 hasAuthorship W1978309095A5068240015 @default.
- W1978309095 hasAuthorship W1978309095A5068498952 @default.
- W1978309095 hasConcept C126322002 @default.
- W1978309095 hasConcept C147483822 @default.
- W1978309095 hasConcept C159654299 @default.
- W1978309095 hasConcept C163764329 @default.
- W1978309095 hasConcept C203014093 @default.
- W1978309095 hasConcept C2776029263 @default.
- W1978309095 hasConcept C2777075537 @default.
- W1978309095 hasConcept C2777203481 @default.
- W1978309095 hasConcept C2777214474 @default.
- W1978309095 hasConcept C2779075594 @default.
- W1978309095 hasConcept C2779102576 @default.
- W1978309095 hasConcept C32611913 @default.
- W1978309095 hasConcept C71924100 @default.
- W1978309095 hasConceptScore W1978309095C126322002 @default.
- W1978309095 hasConceptScore W1978309095C147483822 @default.
- W1978309095 hasConceptScore W1978309095C159654299 @default.
- W1978309095 hasConceptScore W1978309095C163764329 @default.
- W1978309095 hasConceptScore W1978309095C203014093 @default.
- W1978309095 hasConceptScore W1978309095C2776029263 @default.
- W1978309095 hasConceptScore W1978309095C2777075537 @default.
- W1978309095 hasConceptScore W1978309095C2777203481 @default.
- W1978309095 hasConceptScore W1978309095C2777214474 @default.
- W1978309095 hasConceptScore W1978309095C2779075594 @default.
- W1978309095 hasConceptScore W1978309095C2779102576 @default.
- W1978309095 hasConceptScore W1978309095C32611913 @default.
- W1978309095 hasConceptScore W1978309095C71924100 @default.
- W1978309095 hasIssue "1" @default.
- W1978309095 hasLocation W19783090951 @default.
- W1978309095 hasLocation W19783090952 @default.
- W1978309095 hasOpenAccess W1978309095 @default.
- W1978309095 hasPrimaryLocation W19783090951 @default.
- W1978309095 hasRelatedWork W1636117061 @default.
- W1978309095 hasRelatedWork W1978309095 @default.
- W1978309095 hasRelatedWork W2008359073 @default.
- W1978309095 hasRelatedWork W2016840028 @default.
- W1978309095 hasRelatedWork W2063966917 @default.
- W1978309095 hasRelatedWork W2089465242 @default.
- W1978309095 hasRelatedWork W2390771550 @default.
- W1978309095 hasRelatedWork W2409279189 @default.
- W1978309095 hasRelatedWork W2412733333 @default.
- W1978309095 hasRelatedWork W3189521416 @default.
- W1978309095 hasVolume "43" @default.
- W1978309095 isParatext "false" @default.
- W1978309095 isRetracted "false" @default.
- W1978309095 magId "1978309095" @default.
- W1978309095 workType "article" @default.