Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978316667> ?p ?o ?g. }
- W1978316667 endingPage "6115" @default.
- W1978316667 startingPage "6110" @default.
- W1978316667 abstract "M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1 + cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin β receptor (LTβR)-Ig-treated, lymphotoxin α (LTα) -/- , tumor necrosis factor/LTα -/- , and inhibition of differentiation 2 (Id2) -/- mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia , and Escherichia coli -expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment." @default.
- W1978316667 created "2016-06-24" @default.
- W1978316667 creator A5000306487 @default.
- W1978316667 creator A5015413462 @default.
- W1978316667 creator A5020193000 @default.
- W1978316667 creator A5023062820 @default.
- W1978316667 creator A5032495081 @default.
- W1978316667 creator A5034494690 @default.
- W1978316667 creator A5037489912 @default.
- W1978316667 creator A5043291280 @default.
- W1978316667 creator A5051450662 @default.
- W1978316667 creator A5052633242 @default.
- W1978316667 creator A5062022557 @default.
- W1978316667 creator A5065377682 @default.
- W1978316667 creator A5074466220 @default.
- W1978316667 creator A5082923252 @default.
- W1978316667 creator A5084452013 @default.
- W1978316667 creator A5087178931 @default.
- W1978316667 date "2004-04-07" @default.
- W1978316667 modified "2023-10-14" @default.
- W1978316667 title "Intestinal villous M cells: An antigen entry site in the mucosal epithelium" @default.
- W1978316667 cites W1536921710 @default.
- W1978316667 cites W1579102917 @default.
- W1978316667 cites W1649341603 @default.
- W1978316667 cites W1672275595 @default.
- W1978316667 cites W175053252 @default.
- W1978316667 cites W1790588053 @default.
- W1978316667 cites W1841963910 @default.
- W1978316667 cites W1845975704 @default.
- W1978316667 cites W1850017326 @default.
- W1978316667 cites W1906564878 @default.
- W1978316667 cites W1961969653 @default.
- W1978316667 cites W1966130292 @default.
- W1978316667 cites W1969540615 @default.
- W1978316667 cites W1973125631 @default.
- W1978316667 cites W1987907874 @default.
- W1978316667 cites W1988562333 @default.
- W1978316667 cites W1998162290 @default.
- W1978316667 cites W2002822654 @default.
- W1978316667 cites W2003111539 @default.
- W1978316667 cites W2007555094 @default.
- W1978316667 cites W2008132225 @default.
- W1978316667 cites W2014958998 @default.
- W1978316667 cites W2020211390 @default.
- W1978316667 cites W2023712945 @default.
- W1978316667 cites W2035177961 @default.
- W1978316667 cites W2035965693 @default.
- W1978316667 cites W2040711587 @default.
- W1978316667 cites W2041354260 @default.
- W1978316667 cites W2050016905 @default.
- W1978316667 cites W2050634031 @default.
- W1978316667 cites W2054721944 @default.
- W1978316667 cites W2062179362 @default.
- W1978316667 cites W2073195728 @default.
- W1978316667 cites W2081226705 @default.
- W1978316667 cites W2102366732 @default.
- W1978316667 cites W2118019637 @default.
- W1978316667 cites W2118762743 @default.
- W1978316667 cites W2126197220 @default.
- W1978316667 cites W2141037169 @default.
- W1978316667 cites W2145949638 @default.
- W1978316667 cites W2146774029 @default.
- W1978316667 cites W2146847333 @default.
- W1978316667 cites W2157265156 @default.
- W1978316667 cites W2185510425 @default.
- W1978316667 cites W31581040 @default.
- W1978316667 cites W85976264 @default.
- W1978316667 doi "https://doi.org/10.1073/pnas.0400969101" @default.
- W1978316667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/395931" @default.
- W1978316667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15071180" @default.
- W1978316667 hasPublicationYear "2004" @default.
- W1978316667 type Work @default.
- W1978316667 sameAs 1978316667 @default.
- W1978316667 citedByCount "416" @default.
- W1978316667 countsByYear W19783166672012 @default.
- W1978316667 countsByYear W19783166672013 @default.
- W1978316667 countsByYear W19783166672014 @default.
- W1978316667 countsByYear W19783166672015 @default.
- W1978316667 countsByYear W19783166672016 @default.
- W1978316667 countsByYear W19783166672017 @default.
- W1978316667 countsByYear W19783166672018 @default.
- W1978316667 countsByYear W19783166672019 @default.
- W1978316667 countsByYear W19783166672020 @default.
- W1978316667 countsByYear W19783166672021 @default.
- W1978316667 countsByYear W19783166672022 @default.
- W1978316667 countsByYear W19783166672023 @default.
- W1978316667 crossrefType "journal-article" @default.
- W1978316667 hasAuthorship W1978316667A5000306487 @default.
- W1978316667 hasAuthorship W1978316667A5015413462 @default.
- W1978316667 hasAuthorship W1978316667A5020193000 @default.
- W1978316667 hasAuthorship W1978316667A5023062820 @default.
- W1978316667 hasAuthorship W1978316667A5032495081 @default.
- W1978316667 hasAuthorship W1978316667A5034494690 @default.
- W1978316667 hasAuthorship W1978316667A5037489912 @default.
- W1978316667 hasAuthorship W1978316667A5043291280 @default.
- W1978316667 hasAuthorship W1978316667A5051450662 @default.
- W1978316667 hasAuthorship W1978316667A5052633242 @default.
- W1978316667 hasAuthorship W1978316667A5062022557 @default.