FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978317029> ?p ?o ?g. }

• W1978317029 endingPage "4012" @default.
• W1978317029 startingPage "4006" @default.
• W1978317029 abstract "A method is described whereby a family of homologues is synthesized in a one-pot reaction, without isolation or purification, and the reaction mixture is screened using a competitive binding assay based on pulsed ultrafiltration/electrospray mass spectrometry (PUF/ESMS) to tentatively identify those derivatives having the highest affinity for a target receptor. As a model system to test this approach, a synthetic scheme designed to prepare a series of analogues of the adenosine deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA), as diastereomeric mixtures, was carried out. Pulsed ultrafiltration screening of the crude reaction mixture against controls without protein detected protonated molecules corresponding to EHNA-type derivatives and three of its linear, alkyl homologues but did not show protonated molecules for an isobutyl or benzylic EHNA derivative, suggesting the latter was inactive. To verify this conclusion, we prepared E/THNA, the linear homologues, and the benzylic derivative (each as a diastereomeric mixture) and bioassayed them for them adenosine deaminase inhibition index ([I]/[S]0.5). The bioassay results for the individually synthesized analogues were in good agreement with that predicted by the observed relative ion enhancement in the PUF experiments. Thus, the PUF protocol might be used as a general method to quickly provide direction to the chemist in search of drug candidates." @default.
• W1978317029 created "2016-06-24" @default.
• W1978317029 creator A5001135189 @default.
• W1978317029 creator A5009140739 @default.
• W1978317029 creator A5009595717 @default.
• W1978317029 creator A5023628684 @default.
• W1978317029 creator A5026872517 @default.
• W1978317029 creator A5051225130 @default.
• W1978317029 creator A5054374379 @default.
• W1978317029 date "1997-12-01" @default.
• W1978317029 modified "2023-10-18" @default.
• W1978317029 title "Screening Solution-Phase Combinatorial Libraries Using Pulsed Ultrafiltration/Electrospray Mass Spectrometry" @default.
• W1978317029 cites W1970156566 @default.
• W1978317029 cites W1986170186 @default.
• W1978317029 cites W1994503397 @default.
• W1978317029 cites W2031415145 @default.
• W1978317029 cites W2041719513 @default.
• W1978317029 cites W2042662803 @default.
• W1978317029 cites W2056929095 @default.
• W1978317029 cites W2070903431 @default.
• W1978317029 cites W2092397081 @default.
• W1978317029 cites W2949206075 @default.
• W1978317029 cites W2950359502 @default.
• W1978317029 cites W2952006247 @default.
• W1978317029 cites W4235119634 @default.
• W1978317029 doi "https://doi.org/10.1021/jm960729b" @default.
• W1978317029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9406591" @default.
• W1978317029 hasPublicationYear "1997" @default.
• W1978317029 type Work @default.
• W1978317029 sameAs 1978317029 @default.
• W1978317029 citedByCount "58" @default.
• W1978317029 countsByYear W19783170292012 @default.
• W1978317029 countsByYear W19783170292013 @default.
• W1978317029 countsByYear W19783170292014 @default.
• W1978317029 countsByYear W19783170292015 @default.
• W1978317029 countsByYear W19783170292016 @default.
• W1978317029 countsByYear W19783170292017 @default.
• W1978317029 countsByYear W19783170292019 @default.
• W1978317029 countsByYear W19783170292020 @default.
• W1978317029 countsByYear W19783170292021 @default.
• W1978317029 countsByYear W19783170292022 @default.
• W1978317029 crossrefType "journal-article" @default.
• W1978317029 hasAuthorship W1978317029A5001135189 @default.
• W1978317029 hasAuthorship W1978317029A5009140739 @default.
• W1978317029 hasAuthorship W1978317029A5009595717 @default.
• W1978317029 hasAuthorship W1978317029A5023628684 @default.
• W1978317029 hasAuthorship W1978317029A5026872517 @default.
• W1978317029 hasAuthorship W1978317029A5051225130 @default.
• W1978317029 hasAuthorship W1978317029A5054374379 @default.
• W1978317029 hasConcept C138716334 @default.
• W1978317029 hasConcept C145148216 @default.
• W1978317029 hasConcept C162356407 @default.
• W1978317029 hasConcept C178790620 @default.
• W1978317029 hasConcept C185592680 @default.
• W1978317029 hasConcept C194451485 @default.
• W1978317029 hasConcept C21951064 @default.
• W1978317029 hasConcept C30095370 @default.
• W1978317029 hasConcept C31827203 @default.
• W1978317029 hasConcept C32909587 @default.
• W1978317029 hasConcept C40684141 @default.
• W1978317029 hasConcept C43617362 @default.
• W1978317029 hasConcept C50817676 @default.
• W1978317029 hasConcept C71043704 @default.
• W1978317029 hasConcept C71240020 @default.
• W1978317029 hasConceptScore W1978317029C138716334 @default.
• W1978317029 hasConceptScore W1978317029C145148216 @default.
• W1978317029 hasConceptScore W1978317029C162356407 @default.
• W1978317029 hasConceptScore W1978317029C178790620 @default.
• W1978317029 hasConceptScore W1978317029C185592680 @default.
• W1978317029 hasConceptScore W1978317029C194451485 @default.
• W1978317029 hasConceptScore W1978317029C21951064 @default.
• W1978317029 hasConceptScore W1978317029C30095370 @default.
• W1978317029 hasConceptScore W1978317029C31827203 @default.
• W1978317029 hasConceptScore W1978317029C32909587 @default.
• W1978317029 hasConceptScore W1978317029C40684141 @default.
• W1978317029 hasConceptScore W1978317029C43617362 @default.
• W1978317029 hasConceptScore W1978317029C50817676 @default.
• W1978317029 hasConceptScore W1978317029C71043704 @default.
• W1978317029 hasConceptScore W1978317029C71240020 @default.
• W1978317029 hasIssue "25" @default.
• W1978317029 hasLocation W19783170291 @default.
• W1978317029 hasLocation W19783170292 @default.
• W1978317029 hasOpenAccess W1978317029 @default.
• W1978317029 hasPrimaryLocation W19783170291 @default.
• W1978317029 hasRelatedWork W1978258542 @default.
• W1978317029 hasRelatedWork W1979241870 @default.
• W1978317029 hasRelatedWork W1993721378 @default.
• W1978317029 hasRelatedWork W2007390411 @default.
• W1978317029 hasRelatedWork W2022873267 @default.
• W1978317029 hasRelatedWork W2041651069 @default.
• W1978317029 hasRelatedWork W2126902475 @default.
• W1978317029 hasRelatedWork W2556850201 @default.
• W1978317029 hasRelatedWork W2608736974 @default.
• W1978317029 hasRelatedWork W4200544467 @default.
• W1978317029 hasVolume "40" @default.
• W1978317029 isParatext "false" @default.
• W1978317029 isRetracted "false" @default.
• W1978317029 magId "1978317029" @default.

• next