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• W1978318965 endingPage "e25238" @default.
• W1978318965 startingPage "e25238" @default.
• W1978318965 abstract "Toll-like receptors (TLRs) have long been known for their ability to initiate innate immune responses upon exposure to conserved microbial components such as lipopolysaccharide (LPS) and double-stranded RNA. More recently, this family of pattern recognition receptors has been attributed a critical role in the elicitation of anticancer immune responses, raising interest in the development of immunochemotherapeutic regimens based on natural or synthetic TLR agonists. In spite of such an intense wave of preclinical and clinical investigation, only three TLR agonists are currently licensed by FDA for use in cancer patients: bacillus Calmette–Guérin (BCG), an attenuated strain of Mycobacterium bovis that operates as a mixed TLR2/TLR4 agonist; monophosphoryl lipid A (MPL), a derivative of Salmonella minnesota that functions as a potent agonist of TLR4; and imiquimod, a synthetic imidazoquinoline that activates TLR7. One year ago, in the August and September issues of OncoImmunology, we described the main biological features of TLRs and discussed the progress of clinical studies evaluating the safety and therapeutic potential of TLR agonists in cancer patients. Here, we summarize the latest developments in this exciting area of research, focusing on preclinical studies that have been published during the last 13 mo and clinical trials launched in the same period to investigate the antineoplastic activity of TLR agonists." @default.
• W1978318965 created "2016-06-24" @default.
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• W1978318965 date "2013-08-01" @default.
• W1978318965 modified "2023-10-08" @default.
• W1978318965 title "Trial Watch" @default.
• W1978318965 cites W1483162601 @default.
• W1978318965 cites W1501761310 @default.
• W1978318965 cites W1513881469 @default.
• W1978318965 cites W1514540900 @default.
• W1978318965 cites W1519633296 @default.
• W1978318965 cites W1545200717 @default.
• W1978318965 cites W1545754268 @default.
• W1978318965 cites W1568165627 @default.
• W1978318965 cites W1615242172 @default.
• W1978318965 cites W1709679640 @default.
• W1978318965 cites W1899375067 @default.
• W1978318965 cites W1929515229 @default.
• W1978318965 cites W1952012149 @default.
• W1978318965 cites W1964196894 @default.
• W1978318965 cites W1965702739 @default.
• W1978318965 cites W1965805984 @default.
• W1978318965 cites W1966266819 @default.
• W1978318965 cites W1966339569 @default.
• W1978318965 cites W1966490934 @default.
• W1978318965 cites W1966680360 @default.
• W1978318965 cites W1966921390 @default.
• W1978318965 cites W1969072247 @default.
• W1978318965 cites W1969354039 @default.
• W1978318965 cites W1969423849 @default.
• W1978318965 cites W1969973498 @default.
• W1978318965 cites W1970291282 @default.
• W1978318965 cites W1970916626 @default.
• W1978318965 cites W1971581835 @default.
• W1978318965 cites W1971860559 @default.
• W1978318965 cites W1972430193 @default.
• W1978318965 cites W1972776583 @default.
• W1978318965 cites W1973659410 @default.
• W1978318965 cites W1974541550 @default.
• W1978318965 cites W1975409903 @default.
• W1978318965 cites W1976208319 @default.
• W1978318965 cites W1976910093 @default.
• W1978318965 cites W1977167249 @default.
• W1978318965 cites W1977267072 @default.
• W1978318965 cites W1977957999 @default.
• W1978318965 cites W1978063849 @default.
• W1978318965 cites W1978415870 @default.
• W1978318965 cites W1979387900 @default.
• W1978318965 cites W1979395539 @default.
• W1978318965 cites W1979762906 @default.
• W1978318965 cites W1980294712 @default.
• W1978318965 cites W1980351020 @default.
• W1978318965 cites W1982061062 @default.
• W1978318965 cites W1982467804 @default.
• W1978318965 cites W1983714271 @default.
• W1978318965 cites W1986373360 @default.
• W1978318965 cites W1987541993 @default.
• W1978318965 cites W1989326997 @default.
• W1978318965 cites W1992000721 @default.
• W1978318965 cites W1992058698 @default.
• W1978318965 cites W1992315309 @default.
• W1978318965 cites W1992476510 @default.
• W1978318965 cites W1993517541 @default.
• W1978318965 cites W1994391392 @default.
• W1978318965 cites W1996726345 @default.
• W1978318965 cites W1997874262 @default.
• W1978318965 cites W1997894139 @default.
• W1978318965 cites W1997952190 @default.
• W1978318965 cites W1998637232 @default.
• W1978318965 cites W1999182967 @default.
• W1978318965 cites W1999847045 @default.
• W1978318965 cites W2000559124 @default.
• W1978318965 cites W2001020866 @default.
• W1978318965 cites W2002330167 @default.
• W1978318965 cites W2002601689 @default.
• W1978318965 cites W2003639759 @default.
• W1978318965 cites W2005482601 @default.
• W1978318965 cites W2008215152 @default.
• W1978318965 cites W2008343563 @default.
• W1978318965 cites W2008797060 @default.
• W1978318965 cites W2009093325 @default.
• W1978318965 cites W2010034816 @default.
• W1978318965 cites W2010760893 @default.
• W1978318965 cites W2012194014 @default.
• W1978318965 cites W2012779526 @default.
• W1978318965 cites W2013469022 @default.
• W1978318965 cites W2014311023 @default.
• W1978318965 cites W2014830013 @default.
• W1978318965 cites W2015665561 @default.
• W1978318965 cites W2015719197 @default.
• W1978318965 cites W2016451291 @default.
• W1978318965 cites W2018354452 @default.

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