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- W1978320510 abstract "Some new complexes of diclofenac with potentially interesting biological activity are described. The complexes of diclofenac [MnL2(H2O)], [CoL2(H2O)2]·0.5H2O, [CoL2(H2O)], [NiL2(H2O)2]·2H2O, and [NiL2], were prepared by the reaction of the sodium salt, of a potent anti-inflammatory drug with MnCl2, CoCl2 and NiCl2·6H2O. Optical, EPR, infrared and electrochemical properties of these new complexes are reported. Both five and six-coordinated species were isolated in the solid state for Co(II). Both four and six-coordinated species were isolated in the solid state for Ni(II), while in DMF or MeOH solution predominant formation of six-coordinated species is observed for Co(II) and Ni(II) complexes. The ability of the complexes to catalyze the oxidation of 3,5-di-tert-butyl-o-catechol to 3,5-di-tert-butyl-o-quinone was studied by following the appearance of quinone spectrophotometrically. Correlation of the catalytic activity of these complexes to the reduction potential is reported." @default.
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- W1978320510 date "1998-03-01" @default.
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- W1978320510 title "Metal ion–drug interactions. Preparation and properties of manganese (II), cobalt (II) and nickel (II) complexes of diclofenac with potentially interesting anti-inflammatory activity: Behavior in the oxidation of 3,5-di-tert-butyl-o-catechol" @default.
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- W1978320510 doi "https://doi.org/10.1016/s0162-0134(97)10024-1" @default.
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