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- W1978321775 abstract "The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending on disease etiology and/or timing. Thus far, these studies indicate that substance P may be protective acutely following ischemia-reperfusion, but damaging long-term in non-ischemic induced remodeling and heart failure. Sensory nerves may be at the apex of the cascade of events leading to heart failure, therefore, they make a promising potential therapeutic target that warrants increased investigation." @default.
- W1978321775 created "2016-06-24" @default.
- W1978321775 creator A5056099515 @default.
- W1978321775 creator A5059919343 @default.
- W1978321775 date "2014-01-01" @default.
- W1978321775 modified "2023-09-25" @default.
- W1978321775 title "Substance P in heart failure: The good and the bad" @default.
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- W1978321775 doi "https://doi.org/10.1016/j.ijcard.2013.11.010" @default.
- W1978321775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4450674" @default.
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