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- W1978321893 abstract "Tetracycline blocked the synthesis of polyphenylalanine from phenylalanyl-sRNA. This inhibition was reversed by increased ribosomes plus poly U in the incubation mixture but not by increased aminoacyl-sRNA or supernatant fraction. In contrast to the lack of effect of puromycin and chloramphenicol, tetracycline reduced the binding of N-acetyl-phenylalanyl-sRNA to ribosomes, whereas the binding of poly U to ribosomes was unaffected. Although polyphenylalanine synthesis was inhibited almost completely by tetracycline, aminoacyl-sRNA binding to ribosomes was inhibited maximally about 50 per cent. We suggest that tetracycline may combine with ribosomes in such a way as to obstruct one of the two sites for the binding of aminoacyl-sRNA." @default.
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- W1978321893 date "1965-03-01" @default.
- W1978321893 modified "2023-09-25" @default.
- W1978321893 title "Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline" @default.
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- W1978321893 doi "https://doi.org/10.1016/0006-291x(65)90848-x" @default.
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