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- W1978330296 abstract "310 It has been shown in animal experiments that brain death results in upregulation of cytokine production and MHC antigen expression and acceleration of acute rejection. We hypothesize that cadaver donor is a risk factor for acute rejection as the donor is brain dead with upregulation of cytokine release and MHC antigen expression. To test this hypothesis, we analyzed kidney transplants (KTX) with a minimum followup of 1 year using UNOS database. Methods: We compared the incidence of acute rejection (clinical) within the first year in cadaver KTXs to that of living unrelated KTXs and 1 haplotype matched living related KTXs. Cadaver KTXs with delayed graft function (DGF) were analyzed separately from those without DGF. A multivariate logistic regression analysis was performed to determine whether cadaver donor is an independent risk factor for rejection. Results: The incidence of acute rejection is significantly higher in the cadaver donor KTXs with and without DGF compared to living unrelated and 1 haplotype matched living related KTXs (p < 0.0001) as shown in the following Table. Multivariate logistic regression analysis revealed that recipient race (all others vs caucasians), DGF, poor HLA matching, high PRA, no antilymphocyte induction and cadaver donor were independent risk factors for acute rejection.TableConclusions: Cadaver donor is an independent risk factor for acute rejection along with other known risk factors including race, DGF, poor HLA matching, high PRA, and no antilymphocyte induction. Attempts to modulate the cytokine release and MHC antigen expression in cadaver donors may be another approach to decrease the incidence of acute rejection." @default.
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- W1978330296 date "1999-05-01" @default.
- W1978330296 modified "2023-10-17" @default.
- W1978330296 title "IS CADAVER DONOR A RISK FACTOR FOR ACUTE REJECTION?" @default.
- W1978330296 doi "https://doi.org/10.1097/00007890-199905150-00334" @default.
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