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- W1978332997 abstract "Abstract The effect of multiple doses of cadmium on insulin secretion from the perfused pancreas was studied. In addition, urine and plasma glucose, plasma immunoreactive insulin, and the rate of evolution of respiratory 14CO2 after administration of [UL-14C] d -glucose were determined. The treated groups received two dose levels, 0.25 or 0.50 mg Cd/kg, ip every second day for 70 doses. Multiple doses of 0.50 mg/kg caused an inhibition in the amount of insulin secreted from the perfused pancreas, whereas multiple doses of 0.25 mg/kg caused a partial inhibition that was not statistically significant. With the exception of the plasma insulin concentration in animals receiving multiple doses of 0.50 mg/kg, statistically significant differences in the plasma glucose, plasma insulin, and insulinogenic index were not detected. A high glucose concentration as well as a high concentration of 14C in the urine of treated animals was found. Treated animals expired smaller amounts of 14CO2 than the controls. Animals receiving the higher dose showed significantly lower weights than either the controls or the animals receiving the lower dose, which did not differ significantly from each other." @default.
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- W1978332997 date "1975-01-01" @default.
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- W1978332997 title "Effect of multiple doses of cadmium on glucose metabolism and insulin secretion in the rat" @default.
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- W1978332997 doi "https://doi.org/10.1016/0041-008x(75)90062-9" @default.
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