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- W1978334548 abstract "Summary Asthma is a common disease with an increasing prevalence worldwide. Up to 10% of these patients have asthma that is refractory to current therapy. This group have a disproportionate use of health care resources attributed to asthma, have significant morbidity and mortality and therefore represent an unmet clinical need. Asthma is a complex heterogeneous condition that is characterized by typical symptoms and disordered airway physiology set against a background of airway inflammation and remodelling. The inflammatory process underlying asthma is co-ordinated by a cytokine network. Modulating this network with biological therapy presents a new paradigm for asthma treatment. Clinical trials undertaken to date have underscored the complexity of the inflammatory profile and its relationship to the clinical features of the disease and have raised the importance of safety considerations related to these novel therapies. T helper type 2 cytokine blockade remains the most promising strategy, with anti-interleukin-5 reducing asthma exacerbations. Although anti-cytokine therapy is not yet ready for the clinic, the long-awaited possibility of new treatments for severe asthma is moving ever closer." @default.
- W1978334548 created "2016-06-24" @default.
- W1978334548 creator A5048320859 @default.
- W1978334548 creator A5069887200 @default.
- W1978334548 date "2009-07-15" @default.
- W1978334548 modified "2023-09-27" @default.
- W1978334548 title "Cytokine and anti-cytokine therapy in asthma: ready for the clinic?" @default.
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- W1978334548 doi "https://doi.org/10.1111/j.1365-2249.2009.03998.x" @default.
- W1978334548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759053" @default.
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