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• W1978340787 abstract "Vulvovaginal candidiasis is a common mucosal fungal infection in women of child-bearing ages. Despite the role for cell-mediated immunity and T cells in host protection against the majority of mucosal Candida albicans infections, there is controversy as to whether immunosuppression by HIV infection enhances susceptibility to vaginal candidiasis. To date, host defense against C. albicans vaginitis has been studied in women with recurrent vaginitis, in HIV-infected women, and in animal models of experimental vaginitis. Together, data suggest that local immunity is more important than that in the systemic circulation for host defense against vaginitis. Thus, current investigations have been focused specifically on innate and acquired immune responses against C. albicans at the vaginal mucosa. This review will discuss the current knowledge of host defenses against C. albicans vaginitis, both systemically and locally, and try to shed some light on several issues surrounding the efficiency of this seemingly compartmentalized immune response." @default.
• W1978340787 created "2016-06-24" @default.
• W1978340787 creator A5001887961 @default.
• W1978340787 date "1998-05-01" @default.
• W1978340787 modified "2023-09-23" @default.
• W1978340787 title "Vaginal Candidiasis: Review and Role of Local Mucosal Immunity" @default.
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• W1978340787 doi "https://doi.org/10.1089/apc.1998.12.359" @default.
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