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• W1978341764 endingPage "282" @default.
• W1978341764 startingPage "268" @default.
• W1978341764 abstract "Autism is a neurodevelopmental disorder in which the first diagnostic symptom is unusual reciprocal social interactions. Approximately half of the children diagnosed with an autism spectrum disorder also have intellectual impairments. General cognitive abilities may be fundamental to many aspects of social cognition. Cognitive enhancers could conceivably be of significant benefit to children and adults with autism. AMPAKINE compounds are a novel class of pharmacological agents that act as positive modulators of AMPA receptors to enhance excitatory glutamatergic neurotransmission. This class of compounds was reported to improve learning and memory in several rodent and non-human primate tasks, and to normalize respiratory abnormalities in a mouse model of Rett syndrome. Here we evaluate the actions of AMPA compounds in adult male and female BTBR mice, a well characterized mouse model of autism. Acute treatment with CX1837 and CX1739 reversed the deficit in sociability in BTBR mice on the most sensitive parameter, time spent sniffing a novel mouse as compared to time spent sniffing a novel object. The less sensitive parameter, time in the chamber containing the novel mouse versus time in the chamber containing the novel object, was not rescued by CX1837 or CX1739 treatment. Preliminary data with CX546, in which β-cyclodextrin was the vehicle, revealed behavioral effects of the acute intraperitoneal and oral administration of vehicle alone. To circumvent the artifacts introduced by the vehicle administration, we employed a novel treatment regimen using pellets of peanut butter for drug delivery. Absence of vehicle treatment effects when CX1837 and CX1739 were given in the peanut butter pellets, to multiple cohorts of BTBR and B6 control mice, confirmed that the pharmacologically-induced improvements in sociability in BTBR were not confounded by the administration procedures. The highest dose of CX1837 improved the cognitive deficit in novel object recognition in BTBR. No drug effects were detected on the high levels of repetitive self-grooming in BTBR. In open field tests, CX1837 and CX1739 did not induce hyperactivity or sedation in either strain. It is interesting to speculate that the ability of CX1837 and CX1739 to restore aspects of sociability in BTBR mice could utilize synaptic mechanisms regulating social cognition, suggesting a potential pharmacological target for interventions to treat symptoms of autism. This article is part of a Special Issue entitled ‘Cognitive Enhancers’." @default.
• W1978341764 created "2016-06-24" @default.
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• W1978341764 date "2013-01-01" @default.
• W1978341764 modified "2023-10-01" @default.
• W1978341764 title "AMPAKINE enhancement of social interaction in the BTBR mouse model of autism" @default.
• W1978341764 cites W1481250329 @default.
• W1978341764 cites W1526674447 @default.
• W1978341764 cites W1541506878 @default.
• W1978341764 cites W1545157894 @default.
• W1978341764 cites W1575366723 @default.
• W1978341764 cites W1964634661 @default.
• W1978341764 cites W1964935491 @default.
• W1978341764 cites W1970151545 @default.
• W1978341764 cites W1972342243 @default.
• W1978341764 cites W1974071870 @default.
• W1978341764 cites W1974237084 @default.
• W1978341764 cites W1977569817 @default.
• W1978341764 cites W1978783429 @default.
• W1978341764 cites W1979041721 @default.
• W1978341764 cites W1981055374 @default.
• W1978341764 cites W1984005834 @default.
• W1978341764 cites W1986253091 @default.
• W1978341764 cites W1986624564 @default.
• W1978341764 cites W1991626940 @default.
• W1978341764 cites W1992887691 @default.
• W1978341764 cites W1996593944 @default.
• W1978341764 cites W2003064434 @default.
• W1978341764 cites W2003863298 @default.
• W1978341764 cites W2004487905 @default.
• W1978341764 cites W2004777672 @default.
• W1978341764 cites W2008170190 @default.
• W1978341764 cites W2008290809 @default.
• W1978341764 cites W2009443134 @default.
• W1978341764 cites W2013076099 @default.
• W1978341764 cites W2016411894 @default.
• W1978341764 cites W2016971764 @default.
• W1978341764 cites W2017848939 @default.
• W1978341764 cites W2019233469 @default.
• W1978341764 cites W2021091700 @default.
• W1978341764 cites W2023989346 @default.
• W1978341764 cites W2024052269 @default.
• W1978341764 cites W2024552192 @default.
• W1978341764 cites W2028759544 @default.
• W1978341764 cites W2030254267 @default.
• W1978341764 cites W2033844955 @default.
• W1978341764 cites W2035454507 @default.
• W1978341764 cites W2035458333 @default.
• W1978341764 cites W2037835075 @default.
• W1978341764 cites W2042887680 @default.
• W1978341764 cites W2043402111 @default.
• W1978341764 cites W2043660784 @default.
• W1978341764 cites W2043807135 @default.
• W1978341764 cites W2050550932 @default.
• W1978341764 cites W2050686131 @default.
• W1978341764 cites W2050729386 @default.
• W1978341764 cites W2051464199 @default.
• W1978341764 cites W2051942403 @default.
• W1978341764 cites W2052873092 @default.
• W1978341764 cites W2053056530 @default.
• W1978341764 cites W2054086319 @default.
• W1978341764 cites W2054356301 @default.
• W1978341764 cites W2058324506 @default.
• W1978341764 cites W2062250648 @default.
• W1978341764 cites W2062496408 @default.
• W1978341764 cites W2065521724 @default.
• W1978341764 cites W2071797996 @default.
• W1978341764 cites W2072319418 @default.
• W1978341764 cites W2077701571 @default.
• W1978341764 cites W2079463522 @default.
• W1978341764 cites W2081522004 @default.
• W1978341764 cites W2082109123 @default.
• W1978341764 cites W2083657788 @default.
• W1978341764 cites W2088761605 @default.
• W1978341764 cites W2090460252 @default.
• W1978341764 cites W2091028497 @default.
• W1978341764 cites W2093081094 @default.
• W1978341764 cites W2095185373 @default.
• W1978341764 cites W2096704400 @default.
• W1978341764 cites W2097494446 @default.
• W1978341764 cites W2098277878 @default.
• W1978341764 cites W2099388920 @default.
• W1978341764 cites W2099617826 @default.
• W1978341764 cites W2103600744 @default.
• W1978341764 cites W2104541524 @default.
• W1978341764 cites W2105245235 @default.
• W1978341764 cites W2106572779 @default.
• W1978341764 cites W2106637579 @default.
• W1978341764 cites W2115529264 @default.
• W1978341764 cites W2116897762 @default.
• W1978341764 cites W2117928188 @default.
• W1978341764 cites W2119045235 @default.
• W1978341764 cites W2121327279 @default.
• W1978341764 cites W2124249156 @default.

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