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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978345827> ?p ?o ?g. }

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• W1978345827 abstract "A series of hydroxamates (4a–4l) were prepared from p-aminobenzoic acid to inhibit HDAC8. The idea is to substitute rigid aromatic ring in place of less rigid piperazine ring of hydroxamates reported earlier by our group. It is expected to increase potency retaining the selectivity. Result obtained suggested that the modifications carried out retained the selectivity towards HDAC8 isoform and increasing the potency in very few cases. Increase in potency is also associated with variation in cap aryl region. Two compounds (4f & 4l) were found to inhibit HDAC8 at concentrations (IC50) less than 20 μM." @default.
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• W1978345827 date "2014-12-01" @default.
• W1978345827 modified "2023-10-16" @default.
• W1978345827 title "Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8" @default.
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• W1978345827 doi "https://doi.org/10.1016/j.bioorg.2014.08.005" @default.
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