Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978346365> ?p ?o ?g. }
- W1978346365 endingPage "270" @default.
- W1978346365 startingPage "263" @default.
- W1978346365 abstract "Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China: Jie JIAO, et al . Department of Occupational Health and Toxicology, School of Public Health, Fudan University, China— Objectives The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCMexposed workers in central China and validate the published results in Shanghai. Methods VCMexposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis‐block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure. Results The MN frequency in the VCM‐exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCMexposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose‐response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL 10 was found to be 630.6, 670.2 and 273.7 mgyear for all VCM‐exposed workers, males and females, respectively. Conclusions These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity." @default.
- W1978346365 created "2016-06-24" @default.
- W1978346365 creator A5009863660 @default.
- W1978346365 creator A5014683354 @default.
- W1978346365 creator A5015195367 @default.
- W1978346365 creator A5023214008 @default.
- W1978346365 creator A5042524516 @default.
- W1978346365 creator A5045500968 @default.
- W1978346365 creator A5050553458 @default.
- W1978346365 creator A5061954077 @default.
- W1978346365 creator A5062813030 @default.
- W1978346365 creator A5078658095 @default.
- W1978346365 creator A5080455292 @default.
- W1978346365 creator A5083262817 @default.
- W1978346365 creator A5085285424 @default.
- W1978346365 creator A5089087128 @default.
- W1978346365 date "2012-07-01" @default.
- W1978346365 modified "2023-10-18" @default.
- W1978346365 title "Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China" @default.
- W1978346365 cites W1964732362 @default.
- W1978346365 cites W1971154857 @default.
- W1978346365 cites W1974911961 @default.
- W1978346365 cites W1981143902 @default.
- W1978346365 cites W1982418231 @default.
- W1978346365 cites W1983785443 @default.
- W1978346365 cites W1983896552 @default.
- W1978346365 cites W1989593809 @default.
- W1978346365 cites W1989964790 @default.
- W1978346365 cites W1996846499 @default.
- W1978346365 cites W2006441728 @default.
- W1978346365 cites W2009726922 @default.
- W1978346365 cites W2019359230 @default.
- W1978346365 cites W2019514886 @default.
- W1978346365 cites W2020457580 @default.
- W1978346365 cites W2022996581 @default.
- W1978346365 cites W2024264346 @default.
- W1978346365 cites W2043583553 @default.
- W1978346365 cites W2046077065 @default.
- W1978346365 cites W2053728456 @default.
- W1978346365 cites W2067002777 @default.
- W1978346365 cites W2073524391 @default.
- W1978346365 cites W2079720183 @default.
- W1978346365 cites W2086139507 @default.
- W1978346365 cites W2091261621 @default.
- W1978346365 cites W2094265808 @default.
- W1978346365 cites W2103967928 @default.
- W1978346365 cites W2116830509 @default.
- W1978346365 cites W2118610649 @default.
- W1978346365 cites W2132607882 @default.
- W1978346365 cites W2132873473 @default.
- W1978346365 cites W2149177144 @default.
- W1978346365 cites W2149422371 @default.
- W1978346365 cites W2152110544 @default.
- W1978346365 cites W2156760055 @default.
- W1978346365 cites W2156944164 @default.
- W1978346365 cites W2164041388 @default.
- W1978346365 cites W2313745926 @default.
- W1978346365 doi "https://doi.org/10.1539/joh.11-0157-oa" @default.
- W1978346365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22672882" @default.
- W1978346365 hasPublicationYear "2012" @default.
- W1978346365 type Work @default.
- W1978346365 sameAs 1978346365 @default.
- W1978346365 citedByCount "13" @default.
- W1978346365 countsByYear W19783463652013 @default.
- W1978346365 countsByYear W19783463652014 @default.
- W1978346365 countsByYear W19783463652016 @default.
- W1978346365 countsByYear W19783463652017 @default.
- W1978346365 countsByYear W19783463652018 @default.
- W1978346365 countsByYear W19783463652019 @default.
- W1978346365 crossrefType "journal-article" @default.
- W1978346365 hasAuthorship W1978346365A5009863660 @default.
- W1978346365 hasAuthorship W1978346365A5014683354 @default.
- W1978346365 hasAuthorship W1978346365A5015195367 @default.
- W1978346365 hasAuthorship W1978346365A5023214008 @default.
- W1978346365 hasAuthorship W1978346365A5042524516 @default.
- W1978346365 hasAuthorship W1978346365A5045500968 @default.
- W1978346365 hasAuthorship W1978346365A5050553458 @default.
- W1978346365 hasAuthorship W1978346365A5061954077 @default.
- W1978346365 hasAuthorship W1978346365A5062813030 @default.
- W1978346365 hasAuthorship W1978346365A5078658095 @default.
- W1978346365 hasAuthorship W1978346365A5080455292 @default.
- W1978346365 hasAuthorship W1978346365A5083262817 @default.
- W1978346365 hasAuthorship W1978346365A5085285424 @default.
- W1978346365 hasAuthorship W1978346365A5089087128 @default.
- W1978346365 hasBestOaLocation W19783463651 @default.
- W1978346365 hasConcept C126322002 @default.
- W1978346365 hasConcept C146304588 @default.
- W1978346365 hasConcept C147077947 @default.
- W1978346365 hasConcept C15920480 @default.
- W1978346365 hasConcept C178790620 @default.
- W1978346365 hasConcept C185592680 @default.
- W1978346365 hasConcept C2781460079 @default.
- W1978346365 hasConcept C2908647359 @default.
- W1978346365 hasConcept C29730261 @default.
- W1978346365 hasConcept C2987845665 @default.
- W1978346365 hasConcept C33070731 @default.
- W1978346365 hasConcept C36681516 @default.
- W1978346365 hasConcept C45080847 @default.