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• W1978351606 abstract "The c-Myb gene encodes the p75c-Myb isoform and less-abundant proteins generated by alternatively spliced transcripts. Among these, the best known is p89c-Mybex9b, which contains 121 additional amino acids between exon 9 and 10, in a domain involved in protein–protein interactions and negative regulation. In hematopoietic cells, expression of p89c-Mybex9b accounts for 10–15% of total c-Myb; these levels may be biologically relevant because modest changes in c-Myb expression affects proliferation and survival of leukemic cells and lineage choice and frequency of normal hematopoietic progenitors. In this study, we assessed biochemical activities of p89c-Mybex9b and the consequences of perturbing its expression in K562 and primary chronic myeloid leukemia (CML) progenitor cells. Compared with p75c-Myb, p89c-Mybex9b is more stable and more effective in transactivating Myb-regulated promoters. Ectopic expression of p89c-Mybex9b enhanced proliferation and colony formation and reduced imatinib (IM) sensitivity of K562 cells; conversely, specific downregulation of p89c-Mybex9b reduced proliferation and colony formation, enhanced IM sensitivity of K562 cells and markedly suppressed colony formation of CML CD34+ cells, without affecting the levels of p75c-Myb. Together, these studies indicate that expression of the low-abundance p89c-Mybex9b isoform has an important role for the overall biological effects of c-Myb in BCR/ABL-transformed cells." @default.
• W1978351606 created "2016-06-24" @default.
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• W1978351606 date "2012-05-11" @default.
• W1978351606 modified "2023-10-17" @default.
• W1978351606 title "Expression of p89c-Mybex9b, an alternatively spliced form of c-Myb, is required for proliferation and survival of p210BCR/ABL-expressing cells" @default.
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• W1978351606 doi "https://doi.org/10.1038/bcj.2012.16" @default.
• W1978351606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3366069" @default.
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