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- W1978351708 abstract "In numerous fish species, dopamine has been found to strongly inhibit gonadotropin release. Among the enzymes that regulate dopamine turnover, tyrosine hydroxylase (TH), the rate-limiting anabolic enzyme, could be a target for endocrine feedback regulation. Since dopamine turnover is stimulated by estradiol in rainbow trout, we have investigated the effect of estradiol on TH and estradiol receptor expression. In situ hybridization was used to quantify mRNA levels in the brain of ovariectomized female rainbow trout implanted or not with estradiol pellets. We demonstrated that preoptic TH and estradiol receptor mRNA levels are greatly decreased by gonadectomy during vitellogenesis. For TH expression, this effect was reversed in part by estradiol supplementation. We have also confirmed the existence of an inhibitory gonadal feedback on FSH secretion, mediated by estradiol. The stimulating effect of estradiol on TH expression found in this study could be a pathway involved in gonadal feedback on gonadotropin release." @default.
- W1978351708 created "2016-06-24" @default.
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- W1978351708 date "2003-01-01" @default.
- W1978351708 modified "2023-10-18" @default.
- W1978351708 title "Differential regulation of tyrosine hydroxylase and estradiol receptor expression in the rainbow trout brain" @default.
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- W1978351708 doi "https://doi.org/10.1016/s0303-7207(02)00305-2" @default.
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